Endothelial Cell Density Loss
Conditions
Keywords
Endothelial cell, Specular microscopy, Phacoemulsification
Brief summary
The aim of this study is to evaluate and compare specular endothelial changes in diabetic and non-diabetic patients undergoing phacoemulsification by assessing endothelial cell density, coefficient of variation, and percentage of hexagonal cells preoperatively and postoperatively. This study also seeks to provide updated evidence on the influence of diabetes on corneal endothelial response to cataract surgery and to support evidence-based strategies for optimizing surgical outcomes
Interventions
PROCEDUREPhacoemulsification
Cataract surgery using phacoemulsification is the most frequently performed ophthalmic procedure worldwide and is considered a highly effective and safe method for visual rehabilitation
Sponsors
Al-Azhar University
Study design
Allocation
NA
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥ 40 years * Presence of senile cataract suitable for phacoemulsification * Clear cornea with no clinical signs of endothelial decompensation * Ability to undergo specular microscopy examination * For the diabetic group: confirmed diagnosis of type 2 diabetes mellitus
Exclusion criteria
* History of previous ocular surgery or trauma * Corneal pathology affecting the endothelium * Glaucoma or history of raised intraocular pressure * Pseudoexfoliation syndrome * Intraoperative complications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cell density | 1 week |
Countries
Egypt
Outcome results
None listed