Bariatric Surgery, Hair Loss, Metabolomics, Obesity & Overweight
Conditions
Keywords
obesity, hair loss, metabolomics, bariatric surgery
Brief summary
The purpose of this research study is to investigate how body weight and weight-loss surgery affect the natural chemicals found in scalp hair over time. We will also find out how common and severe hair thinning/hair loss and muscle loss are in the first 6 months after bariatric surgery.
Detailed description
The investigators will recruit 30 subjects with severe obesity scheduled for bariatric surgery and 30 healthy-weight controls. Following written informed consent, the investigators will collect the study subject's medical information, conduct a dietary and quality-of-life survey, take body measurements, obtain scalp photos, perform a hair-pull test, collect a hair sample, and conduct muscle strength testing. Controls will be assessed only at baseline. Those with severe obesity will return at 4 ± 2 weeks, 12 ± 4 weeks, and 26 ± 4 weeks following bariatric surgery to repeat the study procedures.
Interventions
None listed
Sponsors
Singapore General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
All subjects: 1. Age 21-70 years 2. Ability to provide informed consent Healthy weight controls: 1. BMI of 18.5-24.9 kg/m2 2. No chronic disease 3. No long-term medications Severe obesity: 1. BMI of \> 32.5 kg/m2 2. Scheduled to undergo bariatric surgery
Exclusion criteria
1. Pregnancy 2. Any factors likely to limit adherence to study protocol 3. Any history of autoimmune or scarring alopecia (eg. alopecia areata, discoid lupus, lichen planopilaris)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amino acid concentration | From enrollment to the end of study duration at 6 months | Post-surgery changes in scalp hair amino acid concentration following bariatric surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Severity of hair loss | From the time of enrolment until the end of the study at 6 months | The severity of hair loss is measured by quantifying the number of hairs lost during the hair pull test |
| Scalp hair amino acid concentration (between groups) | At the time of enrollment | Differences in scalp hair amino acid concentration between controls and those with severe obesity |
| Grip strength | From enrollment until the end of the study at 6 months | The post-surgery changes in grip strength measured using handgrip dynamometer |
| Sit to stand speed | From enrollment until study completion at 6 months | Time taken to complete sit to stand test after bariatric surgery |
| Hair-specific Skindex-29 score | From enrollment until study completion at 6 months | Hair-specific Skindex-29 quality of life questionnaire score after bariatric surgery. scores ranging from 0 (no effect) to 100 (effect always experienced) |
Countries
Singapore
Contacts
CONTACTHong Chang Tan, MD PhD
PRINCIPAL_INVESTIGATORHong Chang Tan
Singapore General Hospital
Outcome results
None listed