Adiposity, Overweight, Overweight and Obesity
Conditions
Keywords
genotype-based nutrition, dietary counseling, weight loss, nutrigenetics
Brief summary
This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.
Interventions
BEHAVIORALGenotype-Based Dietary Counseling
This intervention consists of dietary counseling informed by individual genetic information. Nutrition guidance is provided by qualified nutrition professionals and aims to support weight management and reduction of body fat over the intervention period.
BEHAVIORALStandard Dietary Counseling
This intervention consists of dietary counseling based on general dietary guidelines and standard nutrition recommendations. Counseling is delivered by qualified nutrition professionals without the use of genetic information.
Sponsors
Metropolitan College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged ≥18 years * Body mass index (BMI) ≥25 kg/m² * Greek-speaking (able to read and understand Greek and provide informed consent) * Willing and able to participate in dietary counseling and study assessments for the duration of the study
Exclusion criteria
* Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications * Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions * Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders * Pregnancy or lactation * Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Fat Mass (%) | baseline to end of intervention (12 months) | Change in whole-body fat mass percentage from baseline to end of the intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Body Weight | baseline to end of intervention (12 months) | Change in body weight from baseline to end of the intervention |
| Change in Lipid Profile | baseline to end of intervention (12 months) | Change in fasting lipid profile parameters (e.g., total cholesterol, LDL-C, HDL-C, triglycerides) from baseline to end of the intervention. |
Countries
Greece
Contacts
CONTACTAngeliki Kapellou, PhD
PRINCIPAL_INVESTIGATORAngeliki Kapellou, PhD
Dietetics Department, School of Health Sciences, Metropolitan College
Outcome results
None listed