Impact of Increasing BMI on the Success of Neuraxial Blocks in Class III Obese Parturients

Evaluating the Impact of Increasing BMI on the Success of Neuraxial Blocks in Class III Obese Parturients: A Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07367386

Enrollment

1917

Registered

2026-01-26

Start date

2025-02-02

Completion date

2026-01-01

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuraxial Blocks

Keywords

Neuraxial blocks, Obesity, Parturient, Cesarean

Brief summary

This study seeks to compare the success rates, feto-maternal outcomes, and complications associated with different neuraxial blocks in Class III obese parturient undergoing cesarean section

Detailed description

This was a retrospective cohort study. The data was obtained from electronic medical records of the eligible participants.

Interventions

PROCEDURENeuraxial anesthesia

Single-shot spinal anesthesia

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age \> or equal to 18 years * BMI ≥ 45 kg/m² * Gestational age ≥ 28 weeks

Exclusion criteria

* Age \< 18 years * BMI \< 45 kg/m² * History of venous thromboembolism or arterial disease (e.g., DVT, PE, angina, MI, or stroke) * Severe active lung, cardiovascular, renal, or liver disorders; autoimmune disease; or hemoglobinopathies * Hereditary or acquired thrombophilia (e.g., Factor V Leiden mutation or antithrombin deficiency) * In utero fetal demise (IUFD) * Failed operative vaginal delivery * Cesarean for the second twin or multiple pregnancies (triplets or higher) * IVF pregnancy * Intraoperative bleeding\>1500mL * Emergency cesarean section (Category I) * Presence of large uterine fibroid ≥10 cm

Design outcomes

Primary

Measure	Time frame	Description
Failed neuraxial block	From onset of block until surgery completion	Determine the occurrence of the conversion to general anesthesia

Secondary

Measure	Time frame	Description
Maternal adverse events	From onset of blockade until surgery completion	Determine the incidence of maternal hypotension, bradycardia, high-spinal (above T1 level), level of blockade higher than T4, post-dural puncture headache
Fetal outcomes	At one and five minutes after birth	Apgar score

Countries

Qatar

Contacts

PRINCIPAL_INVESTIGATORAyten Saracoglu

University of Florida, UF Health, Jacksonville, FL 32209, USA

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026