Effect of Increased BMI on Efficacy of Labor Analgesia

The Effect of Increased BMI on Efficacy of Labor Analgesia: A Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07367347

Enrollment

9000

Registered

2026-01-26

Start date

2025-02-02

Completion date

2026-01-01

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuraxial Analgesia, Labor Analgesia

Keywords

labor analgesia, neuraxial analgesia, obesity, parturient

Brief summary

This study seeks to identify the most effective neuraxial technique for labor analgesia in Class III parturient

Detailed description

This retrospective cohort study collected data on eligible participants from the electronic medical records.

Interventions

PROCEDURENeuraxial analgesia

Combined spinal-epidural analgesia

PROCEDURENeuraxial Analgesia

Epidural analgesia

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age \> or equal to 18 years * BMI ≥ 40 kg/m² * Gestational age ≥ 28 weeks

Exclusion criteria

* Age \< 18 years * BMI \< 40 kg/m² * History of venous thromboembolism or arterial disease (e.g., DVT, PE, angina, MI, or stroke) * Severe active lung, cardiovascular, renal, or liver disorders; autoimmune disease; or hemoglobinopathies * Hereditary or acquired thrombophilia (e.g., Factor V Leiden mutation or antithrombin deficiency) * In utero fetal demise (IUFD) * Failed operative vaginal delivery * Cesarean for the second twin or multiple pregnancies (triplets or higher) * IVF pregnancy * Intraoperative bleeding\>1500mL * Emergency cesarean section (Category I) * Presence of large uterine fibroid ≥10 cm.

Design outcomes

Primary

Measure	Time frame	Description
Success rate of labor analgesia	onset of neuraxial analgesia to completion of labor	The success rate of each technique will be determined by: Number of patients requiring a physician top-up bolus Block symmetry First-attempt success rate

Secondary

Measure	Time frame	Description
Maternal adverse events	onset of neuraxial analgesia to completion of labor	Incidence of maternal hypotension, maternal bradycardia, high block (above T1), higher than T4 block, need of vasopressors, mortality, post-Dural puncture headache
Fetal adverse events	at 1 and 5 minutes after birth	APGAR SCORE

Countries

Qatar

Contacts

PRINCIPAL_INVESTIGATORAyten Saracoglu

University of Florida, UF Health, Jacksonville, FL 32209, USA

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026