Down Syndrome
Conditions
Keywords
Down Syndrome, pneumonia, immune, oxygen saturation
Brief summary
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age
Detailed description
descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior to intervention in a larger trial. Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.
Interventions
PROCEDUREPearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.
Sponsors
Badr University
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 6 Years
Healthy volunteers
No
Inclusion criteria
* Down Syndrome with acute bronchopneumonia * sufficient cognitive ability
Exclusion criteria
* severe congenital heart defects * primary immunodeficiencies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum IgG, IgA, IgM | Upon enrollment and prior to any intervention baseline data were collected | Immunoglobulins: Concentrations of IgG(mg/dl) IgA,(mg/dl) and IgM (mg/dl) were determined from serum using an automated nephelometer |
| Respiratory Rate | Upon enrollment and prior to any intervention baseline data were collected | Respiratory rate (breaths/minute) was determined by direct observation and counting of chest wall movements over one full minute |
| Arterial Oxygen Saturation (SaO2) | Upon enrollment and prior to any intervention baseline data were collected | Peripheral oxygen saturation (%) was measured non-invasively via pulse oximetry |
| White Blood Cell count | Upon enrollment and prior to any intervention baseline data were collected | Total WBC count (thousands/mm³) was measured from a whole blood sample using an ADVIA 120 automated hematology analyzer |
Countries
Egypt
Contacts
CONTACTMona Mohamed Abdelkhalek, assistance prof
Outcome results
None listed