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Hyaluronic Acid Mouthwash as Adjunct

Hyaluronic Acid as Adjunctive to Chlorhexidine Mouthwash for Gingivitis: RCT

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07366398
Enrollment
16
Registered
2026-01-26
Start date
2025-02-01
Completion date
2025-05-30
Last updated
2026-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingivitis; Chronic

Brief summary

Patients were instructed to use 2 different mouthwashes after performing professional tooth cleaning. The effect of each of the 2 mouthwashes was detected.

Detailed description

The study tests the efficacy of hyaluronic acid (HYL) mouthwash as adjunct to Chlorhexidine (CHX) mouthwash compared to Chlorhexidine mouthwash only in 16 gingivitis patients. Patients were randomly assigned to either control group received (Chlorhexidine mouthwash) or test group received (hyaluronic acid + Chlorhexidine mouthwash). Clinical parameters and patient reported outcomes as post-operative questionnaire were assessed at baseline and seven days post-operatively.

Interventions

DRUGHyaluoric acid mouthwash

A mouthwash containing both hyaluronic acid

mouthwash of chlorhexidine 0.12%

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
25 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Diagnosed with gingivitis

Exclusion criteria

* pregnant or lactating females and current smokers

Design outcomes

Primary

MeasureTime frameDescription
Bleeding on probing7 days% of gingival sites where bleeding occurred on periodontal probing is registered out of total gingival sites

Secondary

MeasureTime frameDescription
Plaque index7 days% of gingival sites where plaque accumulates is registered out of total gingival sites
Patient's satisfaction questionnaire7 days

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026