Narcolepsy Type 1, REM Sleep Behavior Disorder (iRBD)
Conditions
Keywords
parkinson, REM sleep, pain, REM sleep behavior disorder, narcolepsy Type 1, sleep
Brief summary
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, with over 12 million patients expected globally by 2040. The disease is currently diagnosed at the appearance of motor symptoms, but by then, over 60% of striatal dopaminergic neurons have already been destroyed. Prodromal symptoms such as idiopathic REM Sleep Behavior Disorder (iRBD), anosmia, mood disorders and constipation appear earlier and are listed as criteria for a prodromal PD diagnosis. Identifying early signs is critical to initiate neuroprotective treatments as early as possible. While pain is prevalent and highly disabling in early PD, no data are currently available on pain perception in iRBD patients, whose condition is of the main risk factor for PD development.
Interventions
OTHERThermo test pain
Patients will undergo a pain test, also called a thermotest, which consists of determining pain thresholds using a thermometer applied to the hand.
OTHERPain questionnaires
Patients will complete various questionnaires about pain
OTHERNo motors symptoms evaluations
Patients will complete questionnaires
Sponsors
University Hospital, Toulouse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosed with iRBD confirmed by polysomnography; * No clinical diagnosis of Parkinson's disease or other diagnosis of neurodegenerative disease; * Ability to understand and complete study procedures and questionnaires; Control group: * Diagnosed with narcolepsy type 1; * Coexisting REM sleep behavior disorder confirmed by polysomnography; * Ability to understand and complete study procedures and questionnaires;
Exclusion criteria
* Diagnosed Parkinson's Disease, dementia with Lewy bodies or multiple system atrophy; * Severe depression according to Diagnostic and Statistical Manual of Mental Disorders (DSM V); * Inability to complete study procedures or questionnaires.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of the intensity of chronic pain between patients with iRBD and a control group of patients | 2 hours after the inclusion | Measuring the Visual Analog Scale (VAS) between patients with iRBD without diagnosis of PD and a control group of patients diagnosed with narcolepsy type 1 who present RBD (Rapid eye movement sleep behavior disorder). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Describe semiological characteristics of pain in RBD patients | 2 hours after the inclusion | Description of characteristics of pain |
| Compare the presence of chronic pain | 2 hours after the inclusion | Number of patients with chronic pain in both groups for at least 3 months. |
| Assessing Pain Characteristics | 2 hours after the inclusion | Score obtained on pain questionnaires |
| Assessment of thermal pain threshold and tolerance | 2 hours after the inclusion | Results of the quantitative sensory test (thermal thermotest) in both groups |
| Assessment of correlations between the intensity of chronic pain | 2 hours after the inclusion | Correlation between Visual Analogue Scale (VAS) measurements and questionnaire responses |
Countries
France
Contacts
CONTACTChristine BREFEL COURBON
Outcome results
None listed