Post Operative Analgesia, Third Molar Surgery
Conditions
Keywords
third molar surgery, propolis gargle, chlorhexidine gluconate
Brief summary
The goal of this study is to examine the effects of propolis gargle on wound healing following third molar surgery and to compare it with chlorhexidine gluconate. The main question it aims to answer is: Is propolis-containing gargle safe and effective alternative to chlorhexidine gluconate following impacted third molar surgery? Does propolis demonstrate comparable outcomes in pain control and mouth opening ?
Detailed description
This prospective, randomized clinical study included 52 healthy patients (ASA I) who underwent impacted mandibular third molar surgery. Patients were randomly allocated into two groups: one group used 0.12% chlorhexidine gluconate gargle, while the other used a 3% propolis-containing gargle. Gargles were applied twice daily for one minute from postoperative day 2 to day 7. Pain was evaluated using the visual analog scale (VAS), while edema, maximum mouth opening, wound healing, and postoperative complications were assessed preoperatively and on postoperative days 2 and 7. Statistical significance was set at p \< 0.05.
Interventions
PROCEDUREThird molar Surgery with propolis gargle
The patients were anesthetized with inferior alveolar, lingual, and buccal nerve blocks using 4 ml of articaine with 1:100,000 epinephrine (Ultracaine D-S Fort, Aventis). The tooth could be observed by elevating a full-thickness triangular mucoperiosteal flap. The tooth was extracted following an osteotomy using a bur. The tooth was sectioned and extracted, if required. Curettage was conducted in the presence of a residual dental follicle. The wound was sutured with silk thread. All procedures were conducted by the same physician. Postoperatively, antibiotics (amoxicillin combined with clavulanic acid, 2 g daily for 5 days) and analgesics (paracetamol 1 g, up to 4 times daily for 3 days) were recommended. The group was administered a 3% propolis gargle (formulated in an ethanol solution, twice daily for 1 minute, prepared in the Departments of Pharmacology.
PROCEDUREThird molar surgery with chlorhexidine gluconate
The patients were anesthetized with inferior alveolar, lingual, and buccal nerve blocks using 4 ml of articaine with 1:100,000 epinephrine (Ultracaine D-S Fort, Aventis). The tooth could be observed by elevating a full-thickness triangular mucoperiosteal flap. The tooth was extracted following an osteotomy using a bur. The tooth was sectioned and extracted, if required. Curettage was conducted in the presence of a residual dental follicle. The wound was sutured with silk thread. All procedures were conducted by the same physician. Postoperatively, antibiotics (amoxicillin combined with clavulanic acid, 2 g daily for 5 days) and analgesics (paracetamol 1 g, up to 4 times daily for 3 days) were recommended. The group was administered chlorhexidine gluconate (0.12%) gargle, twice daily for 1 minute.
Sponsors
Ataturk University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of the impacted teeth were classified as Class II level B mesioangular position * Patients from a socioeconomic level who can actively use postoperative gargles
Exclusion criteria
* Individuals with third molars exhibiting acute infection * smokers * pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Edema | Before surgery to after surgery seventh day | Edema (assessed by measuring the distances between the tragus and lip corner, as well as the outer corner of the eye and mandibular corner, with measurements taken twice using a paper ruler and averaged), It was measured before surgery, after surgery second and seventh days. |
| Pain after surgery | After surgery, post- op second and seventh day | Patient records were collected on the second and seventh days post-operation. The evaluated parameters included pain (measured using the VAS scale). Visual analog scale is used to measure pain intensity. It consists of a straight line usually 10 cm. 0: no pain, 10: worst pain imaginable. The patient marks the point that best represents their pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maximum mouth opening | Before surgery to post surgery seventh day | Maximum mouth opening (the distance between the lower and upper incisors) were measured before surgery and after surgery second and seventh day. |
| Wound aperture | From surgery to seventh day after surgery | Wound aperture after surgery was examined for two groups |
Countries
Turkey (Türkiye)
Outcome results
None listed