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Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults

Acute Effects of Structured Physical Exercise and Static Passive Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation: A Randomized Crossover Study

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07364149
Enrollment
27
Registered
2026-01-23
Start date
2025-12-15
Completion date
2026-03-10
Last updated
2026-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation, Static Stretching, Stretch

Keywords

stretching, static stretching, Resistance training, Resistance exercise, tissue stiffness, blood pressure, Flow Mediated Dilation, heart rate variability, Oxygenation

Brief summary

This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition. Participants are allocated to one of three groups (control, resistance training, resistance training plus static stretching) and assessed at baseline, immediately after the session, and 30 minutes post-exercise. Primary outcomes include blood pressure and other hemodynamic or functional measures, in order to explore the short-term impact of these exercise modalities on cardiovascular regulation.

Interventions

OTHERResistance Training

Participants assigned to this group will complete a single supervised upper body resistance training session. The protocol includes bench presses and bicep curls performed at 80% of the individual's 1-rep max, for 4 sets of 8 reps, with standardized rest intervals between sets of 2 minutes. The total duration of the session is approximately 20-30 minutes and does not include any additional static stretching beyond the standardized warm-up.

Participants assigned to this group will complete a single supervised upper body resistance training session. The protocol includes bench presses and bicep curls performed at 80% of the individual's 1-rep max, for 4 sets of 8 reps, with standardized rest intervals between sets of 2 minutes. The total duration of the session is approximately 20-25 minutes .Immediately after the resistance exercises, they will complete a structured static stretching protocol targeting the trained muscle groups (pectoralis and elbow flexors), with each stretch held for about 30 seconds and repeated for several sets. The additional stretching lasts 12 minutes, for a total session duration of about 35-40 minutes.

Sponsors

University of Palermo
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
MALE
Age
18 Years to 55 Years
Healthy volunteers
Yes

Inclusion criteria

* healthy male participants ≥ 18 years old

Exclusion criteria

* orthopedic disorders * neurological disorders * metabolic disorders * cardovascular disorders

Design outcomes

Primary

MeasureTime frameDescription
Flow Mediated Dilation(FMD%)3 times (Baseline, immediately after intervantion and 30 minutes after intervention) for each condition (CC, RT, RT+ST)Brachial artery flow-mediated dilation (FMD) will be assessed using high-resolution B-mode ultrasound (Esaote MyLab X1 GO, linear transducer) during a standardized forearm cuff occlusion protocol. Baseline diameter will be recorded for 60 seconds prior to cuff deflation. Reactive hyperemia will be induced by 5-minutes arterial occlusion followed by cuff release, with continuous diameter recording for 3 minutes post-deflation to identify peak diameter.

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 29, 2026