Atheroma; Carotid Artery, Atheromatosis
Conditions
Keywords
Atheroma, Atherosclerosis, GARP, LRRC32
Brief summary
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in tissue from patients with atherosclerosis, the carotid or femoral plaque representing a good source of residual material adequate for research purpose. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
Interventions
OTHERTissue sample and data collection
Tissue sample and data collection
Sponsors
Université Catholique de Louvain
Fonds National de la Recherche Scientifique
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Older than 18 years * Able to give informed consent * Undergoing carotid or femoral endarterectomy
Exclusion criteria
* Younger than 18 years * Pregnant * Dialysis * Unable to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| GARP Expression in Platelets | Throughout the entire study, approximately during 3 years | The number of cells/area expressing the GARP protein will be assessed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| GARP Expression T Regulating Cells | Throughout the entire study, approximately during 3 years | The number of cells expressing GARP will be assessed as a number of cells / area |
| GARP Expression General | Throughout the entire study, approximately during 3 years | The type of cells expressing GARP will be assessed as a number of cells / area |
Countries
Belgium
Contacts
CONTACTLouis Charki, Medical Degree
PRINCIPAL_INVESTIGATORChristophe Beauloye, Medical Degree
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Outcome results
None listed