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Clear Cell Chondrosarcoma in Italy

Clear Cell Chondrosarcoma in Italy: Insights Into Radiological, Clinical and pathologicaL Features, With Emphasis on Prognosis (CIRCLE)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07360964
Acronym
CIRCLE
Enrollment
77
Registered
2026-01-22
Start date
2025-09-10
Completion date
2026-06-30
Last updated
2026-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chondrosarcoma

Keywords

clear cell chondrosarcoma, prognosis

Brief summary

Clear cell chondrosarcoma of bone is considered a low-grade malignant tumor in the last WHO classification of soft tissue and bone tumors; however, it is reported that recurrences and metastasis can occur. Considering the uncertain prognosis of this rare tumor, with some cases that historically seems to pursue a bad prognosis, we decided to collect all the Italian cases of clear cell condrosarcoma, in order to better understand its natural history and prognosis.

Interventions

GENETICMolecular studies

Molecolar studies to define possible prognostic parameters

Sponsors

Istituto Ortopedico Rizzoli
Lead SponsorOTHER
Azienda Ospedaliera Universitaria Pisana, Pisa
CollaboratorUNKNOWN
Gaetano Pini CTO, Milano
CollaboratorUNKNOWN
IRCCS Humanitas Research Hospital, Milano
CollaboratorUNKNOWN
Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale
CollaboratorNETWORK
Ospedale "Morgagni - Pierantoni" di Forlì
CollaboratorUNKNOWN
AOU Città della Salute e della Scienza Torino
CollaboratorUNKNOWN
Azienda Consorziale Ospedaliero-Universitaria Policlinico di Bari
CollaboratorUNKNOWN

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Male and female patients with diagnosis of clear cell chondrosarcoma and chondrosarcoma with a clear cell component treated from 01 Jan 1982 to 31 Dec 2023 * Information available (date of primary tumor diagnosis, local treatments, systemic treatment, response to systemic treatment, date of progression) and date and status at last follow-up * Imaging studies available for revision * Histological slides available for revision

Exclusion criteria

* \- Diagnosis different from clear cell chondrosarcoma or chondrosarcoma with a clear cell component; * Absence of radiological and/or clinical data

Design outcomes

Primary

MeasureTime frameDescription
Prognostic accuracyAt baselineAbility of the model to predict overall survival, measured by AUC/C-index

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026