Exercise Metabolism
Conditions
Brief summary
The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.
Interventions
OTHERGlucose and fructose (one-to-one)
Glucose and fructose ingested in solution in a one-to-one ratio (135 grams per hour for 3 hours during exercise)
OTHERGlucose and fructose (two-to-one)
Glucose and fructose ingested in solution in a two-to-one ratio (135 grams per hour for 3 hours during exercise)
Sponsors
University of Bath
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age: 18 years and above; * Performing endurance training for at least 5 hours per week * Capable of three hours of continuous exercise
Exclusion criteria
* Glucose or lipid lowering, or weight loss medication * Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes * Contraindications to exercise * Pregnant or lactating
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exogenous carbohydrate oxidation rate (g/h) | 180 minutes | Total exogenous carbohydrate oxidation rate (g/h) over 180 minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peak exogenous carbohydrate oxidation rate (g/h) | 180 minutes | Highest recorded exogenous carbohydrate oxidation rate (g/h) |
| Whole-body carbohydrate oxidation rate (g/h) | 180 minutes | Total whole-body carbohydrate oxidation rate (g/h) |
| Endogenous carbohydrate oxidation rate (g/h) | 180 minutes | Total endogenous carbohydrate oxidation rate (g/h) |
| Whole-body fat oxidation rate (g/h) | 180 minutes | Total whole-body fat oxidation rate (g/h) |
| Blood lactate concentrations (mmol/L) | 180 mninutes | Mean blood lactate concentrations over 180 minutes |
| Blood glucose concentrations (mmol/L) | 180 minutes | Mean blood glucose concentrations (mmol/L) over 180 minutes |
| Ratings of gut comfort (arbitrary units) | 180 minutes | Mean ratings of gut comfort (arbitrary units) over 180 minutes |
| Ratings of perceived exertion (arbitrary units) | 180 minutes | Mean ratings of perceived exertion (arbitrary units) over 180 minutes |
Countries
United Kingdom
Contacts
CONTACTJavier Gonzalez
Outcome results
None listed