Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter

Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Cholecystectomy

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07359508

Acronym

ONSD

Enrollment

146

Registered

2026-01-22

Start date

2024-01-10

Completion date

2025-07-15

Last updated

2026-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Desflurane, Optic Nerve Sheath Diameter, Propofol Target-controlled Infusion

Keywords

propofol, ONSD

Brief summary

effect of propofol vs desflurane on ONSD

Interventions

DRUGDesflurane

In the D group, anesthesia was maintained with oxygen/air (40:60), desflurane, fentanyl and vecuronium

DRUGPropofol (Group P)

In the P group, anesthesia was maintained with oxygen/air (40:60), propofol infusion @50 to 100mcg/kg/min, fentanyl and Vecuronium

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Patient aged 18-60 years ASA grade I or II scheduled for elective laparoscopic cholecystectomy

Exclusion criteria

* patients with ophthalmological and cerebrovascular diseases, systemic infections, psychiatric disorders, pregnancy, Intracranial space occupying lesion, abnormal liver/kidney functions prior myocardial infarction.

Design outcomes

Primary

Measure	Time frame	Description
Optic nerve sheath diameter(ONSD)	before induction, introperative period for every 10 minutes	ONSD will be measured in the operation thetaer

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026