Gingival Recession, Insufficient Keratinized Tissue, Mucogingival Defects
Conditions
Keywords
Free gingival graft, Cyanoacrylate, Sutures, Keratinized tissue, Randomized clinical trial
Brief summary
This randomized controlled clinical trial evaluated the effectiveness of butyl-cyanoacrylate tissue adhesive compared with conventional sutures for stabilization of free gingival grafts. Twenty-four patients with insufficient keratinized tissue were randomly assigned to either cyanoacrylate or suture stabilization following free gingival graft surgery. Clinical parameters, graft dimensional changes, patient-reported postoperative discomfort, and operative time were assessed over a 6-month follow-up period.
Interventions
PROCEDUREFree Gingival Graft Stabilization With Butyl-Cyanoacrylate
Stabilization of free gingival grafts using butyl-cyanoacrylate tissue adhesive following standard free gingival graft surgery.
PROCEDUREFree Gingival Graft Stabilization With Sutures
Stabilization of free gingival grafts using non-resorbable polypropylene sutures following standard free gingival graft surgery.
Sponsors
Yeditepe University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Clinical outcome measurements were performed by an examiner blinded to group allocation.
Intervention model description
Participants were randomly assigned to one of two parallel groups to receive free gingival graft stabilization using either butyl-cyanoacrylate tissue adhesive or conventional sutures.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 18 years or older * Presence of ≤1 mm of keratinized tissue and/or Miller Class I gingival recession ≤2 mm affecting one to four mandibular anterior teeth * Vital teeth in the surgical area * Good oral hygiene following initial periodontal therapy (full-mouth plaque score and full-mouth bleeding score ≤20%) * Ability to understand the study procedures and provide written informed consent
Exclusion criteria
* Current smokers * Pregnancy or lactation * Use of systemic antibiotics within the previous 6 months * History of periodontal surgery in the study area * Ongoing orthodontic treatment * Systemic conditions that could affect periodontal healing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Keratinized Tissue Width | Baseline and 6 months postoperatively | Change in keratinized tissue width measured at the surgical sites using a periodontal probe. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total Graft Surface Area (TGSA) | Baseline, 1 month, 3 months, and 6 months postoperatively | Changes in total graft surface area assessed using standardized clinical photographs and digital measurements. |
| Vertical Graft Height (VGH) | Baseline, 1 month, 3 months, and 6 months postoperatively | Changes in vertical graft height assessed using standardized clinical photographs and digital measurements. |
| Probing Depth (PD) | Baseline and 6 months postoperatively | Changes in probing depth measured at the surgical sites using a periodontal probe. |
| Vertical Recession (VR) | Baseline and 6 months postoperatively | Changes in vertical gingival recession measured at the surgical sites using a periodontal probe. |
| Full-Mouth Plaque Score (FMPS) | Baseline and 6 months postoperatively | Changes in full-mouth plaque score assessed to evaluate oral hygiene status. |
| Full-Mouth Bleeding Score (FMBS) | Baseline and 6 months postoperatively | Changes in full-mouth bleeding score assessed to evaluate periodontal inflammation. |
| Operative Time | During the surgical procedure | Duration of the surgical procedure measured from the initial incision to completion of graft stabilization. |
| Postoperative Pain and Discomfort | Day 0 to Day 6 postoperatively | Patient-reported postoperative pain and discomfort assessed using a visual analogue scale (VAS). |
Countries
Turkey (Türkiye)
Outcome results
None listed