Postoperative Assessment of Platelet-Rich Plasma and Platelet-Rich Fibrin in Temporomandibular Joint Surgery

Postoperative Assessment in TMJ Surgery: A Comparison of the Efficacy of Intraoperative Platelet-Rich Plasma and Platelet-Rich Fibrin Injections

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07359131

Enrollment

700

Registered

2026-01-22

Start date

2026-11-15

Completion date

2027-12-05

Last updated

2026-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporomandibular Joint Disorders

Brief summary

The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders. The study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are: Whether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery. Whether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms. If there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms. Participants will: Have their existing medical records reviewed retrospectively. Provide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

Patients aged 18 to 75 years (inclusive) Underwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy Received intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy

Exclusion criteria

Age younger than 18 years or older than 75 years Did not undergo TMJ arthroscopy Did not receive intraoperative PRP or PRF injection Incomplete clinical or follow-up data

Design outcomes

Primary

Measure	Time frame	Description
pain intensity	from baseline to 6 months post-surgery.	The primary endpoint of the study is the change in pain intensity from baseline to 6 months post-surgery.

Secondary

Measure	Time frame	Description
maximum unassisted opening (MMO)	baseline and various follow-up times in 6 months.	collect data about maximum unassisted opening (MMO)

Countries

United States

Contacts

CONTACTJingping Wang, MD PhD

jwang23@mgh.harvard.edu6179369136

Outcome results