Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective

Adenovirus, Arenavirus Infections, Ascaris Lumbricoides, Brucellosis, Chikungunya, Chlamydia, Clonorchis Sinensis, Cytomegalovirus, Dengue, Diphteria, Entamoeba Histolytica, Enterovirus, Epstein Barr Virus, Giardiasis, Hantavirus Infections, Hepatitis A, Hepatitis E, Human Papilloma Virus (HPV), Influenza A and B, Japanese Encephalitis, Legionella Pneumophila Pneumonia, Leishmaniasis, Leptospirosis, Lymphatic Filariasis, Malaria, Mayaro Fever, Measles, Melioidosis, Meningitis, Mumps, Mycoplasma, Nipah Virus Infection, Norovirus Infections, Opisthorchis Viverrini, Oropouche Fever, Parvovirus, Pertussis, Q Fever, Respiratory Syncytial Virus (RSV), Rhinovirus, Rift Valley Fever, Rotavirus Disease, Rubella, Salmonella Typhi, Schistosomiasis, Severe Fever With Thrombocytopenia Syndrome, Streptococcus Pneumoniae, Strongyloides Stercoralis Infection, Tetanus, Tick-borne Encephalitis (TBE), Toxoplasma Gondii, Trichuris Trichiura, Usutu Virus Infection, Varicella, Vibrio Cholerae, West Nile Virus, Yellow Fever, Zika Virus Infection

Infectious disease, One Health, Population-based survey, Nationally representative survey, Seroepidemiology, Multiplex serology, Seroprevalence, Vector-borne diseases, Zoonoses, Vaccine-preventable diseases, Neglected tropical diseases, Transmission dynamics, Force of infection, Mathematical modelling, Spatial epidemiology, Precision public health, Cambodia

RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics. This knowledge gap hinders the design of effective prevention and control strategies. RACSMEI will improve understanding across multiple pathogens using a multidisciplinary One Health approach. We will answer key questions on burden, ecology, transmission and population immune status to inform targeted and culturally appropriate interventions. The project combines a nationally representative One Health survey, social-science methods, and multiplex, diverse diagnostics to efficiently test for 57 priority pathogens, including zoonotic and vector-borne agents, vaccine-preventable and elimination-targeted diseases, enteric, respiratory, and environmentally transmitted pathogens and selected neglected tropical diseases and parasites relevant to Cambodia. Mathematical modelling will reconstruct and forecast transmission dynamics and assess the potential impact of future public-health strategies. By integrating intersectoral data and innovative methods, RACSMEI will generate actionable evidence for public-health authorities, support precision One Health interventions, and help reduce disease burden in affected communities. The project also aims to ensure the transferability of methods and insights to other countries facing similar challenges.

RACSMEI is a nationwide, One Health, multi-pathogen initiative designed to generate integrated evidence for public-health decision-making in Cambodia. Beyond producing epidemiological findings, the project will establish a structured biobank and curated datasets intended to support long-term collaborative research, knowledge sharing, and evidence-informed policy. The program includes capacity building and technology transfer to strengthen national institutions and foster regional scientific leadership and international collaboration. Engagement with communities and national stakeholders is planned to facilitate future studies and promote the uptake of results in practice. Overall, RACSMEI aims to provide a scalable model for integrated infectious-disease assessment in low- and middle-income settings, creating durable infrastructure, partnerships, and decision-support resources that can be used beyond the project period.

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Cambodia