Prospective Familial Registry for Pancreas Research

Prospective Familial Cohort for Pancreas Research

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07358208

Acronym

PARTNER

Enrollment

3000

Registered

2026-01-22

Start date

2026-01-05

Completion date

2040-11-01

Last updated

2026-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Family History of Pancreas Cancer

Keywords

Family history of pancreas cancer

Brief summary

The purpose of this research is to develop a resource registry of individuals currently without pancreatic cancer but are members of a kindred with two or more blood-related family members with pancreas cancer.

Detailed description

If you agree to be in the study, you will be asked to fill out a questionnaire once every two years. The questionnaire will ask you questions about your health and family history. The investigator may ask you to donate a one-time blood specimen of approximately 3½ tablespoons, which can be done at your local doctor's office. The investigator may ask you if you are willing to provide the names and addresses of other family members who may be eligible to participate in the study. No visits to Mayo Clinic are required for your participation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. An individual who was previously enrolled in Mayo Clinic IRB # 1197-00, 354-06, 355-06, or 19-010791 2. Is age 18 years or older. 3. Has a valid United States mailing address. 4. Has at least two blood-related relatives who have had pancreas cancer or has a blood-relative with pancreatic cancer and that relative carries a known germline mutation in APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53 or mutations in other genes known to be associated with pancreatic cancer.

Exclusion criteria

1. An individual who is a prison inmate 2. An individual who is not compos mentis (of sound mind, memory, and understanding), and not able to give consent. 3. Has personal history of pancreas cancer.

Design outcomes

Primary

Measure	Time frame	Description
To establish a prospective cohort of individuals from pancreas cancer families	25 years	To establish and actively follow a resource registry of individuals currently without pancreatic cancer but are members of a kindred with two or more blood-related family members with pancreas cancer.
Change in health	25 years	Participants will be asked to complete a health questionnaire every 2 years to ascertain new cancer diagnosis in the subject and in first-degree relatives.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORSamuel Antwi, Ph.D.

Mayo Clinic

Outcome results