Oral and Salivary Biomarkers Associated With Stroke

An Observational Study of Oral and Salivary Biomarkers Associated With Stroke

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07357155

Enrollment

120

Registered

2026-01-21

Start date

2026-03-20

Completion date

2026-12-01

Last updated

2026-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

Stroke, Oral health, Salivary biomarkers, Cerebrovascular disease, Observational study

Brief summary

This observational study aims to explore the association between oral and salivary biomarkers and stroke. The study will include adult participants diagnosed with stroke and will analyze clinical, oral, and salivary parameters. The objective is to improve understanding of potential links between oral health, salivary biomarkers, and cerebrovascular disease. No experimental intervention will be performed.

Detailed description

Stroke is a major cause of morbidity and mortality worldwide. Growing scientific evidence suggests that oral health and salivary biomarkers may reflect systemic inflammatory and vascular conditions. This observational study is designed to evaluate associations between oral clinical findings, salivary biomarkers, and stroke. Participants with a confirmed diagnosis of stroke will be enrolled. Data collection will include demographic information, medical history, oral examination findings, and salivary samples. Analyses will focus on identifying correlations between oral and salivary parameters and clinical characteristics of stroke. This study does not involve any therapeutic intervention or experimental treatment. The findings may contribute to a better understanding of the oral-systemic relationship in cerebrovascular diseases and support future preventive strategies.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* Adults aged 18 to 90 years. * Patients diagnosed with stroke (ischemic or hemorrhagic) confirmed by clinical and imaging criteria for the stroke group. * Healthy volunteers without a history of stroke or cerebrovascular disease for the control group. * Ability to provide written informed consent.

Exclusion criteria

* inflammatory disease at the time of sampling. * Chronic autoimmune or malignant disease. * Recent major surgery or trauma within the last 3 months. * Pregnancy or breastfeeding. * Inability or refusal to provide saliva samples.

Design outcomes

Primary

Measure	Time frame	Description
Differences in salivary inflammatory biomarker profiles between stroke patients and healthy controls.	Single time-point assessment at enrollment	Assessment of salivary inflammatory and neuroendocrine biomarkers, including salivary cortisol and selected inflammatory cytokines (e.g., IL-6 and/or hs-CRP), to identify biomarker patterns associated with stroke.

Secondary

Measure	Time frame	Description
Exploratory association between oral microbiota profiles and stroke status	Single time-point assessment at enrollment	Exploratory analysis of the association between oral microbiota profiles and stroke status using saliva or oral swab samples. The analysis aims to identify bacterial profiles potentially associated with stroke and oral-systemic interactions.

Countries

Algeria

Contacts

CONTACTAbdeldjalil Zitouni, DDS

djalil007_dz@yahoo.fr+213550400202

PRINCIPAL_INVESTIGATORAbdeldjalil Zitouni, DDS

Independent Researcher, Constantine, Algeria

Outcome results