Prognostic Nutritional Index for Predicting Outcomes Following Coronary Artery Bypass Grafting (CABG) Surgery

The Merits of the Prognostic Nutritional Index for Prediction of the Outcome of Coronary Artery Bypass Grafting Surgery: A Retrospective Observational Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07356219

Enrollment

117

Registered

2026-01-21

Start date

2025-11-15

Completion date

2026-01-20

Last updated

2026-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Brief summary

Coronary artery bypass grafting (CABG) is a major cardiac surgery associated with risks of serious perioperative complications and mortality. Malnutrition and inflammation are known independent risk factors for poor outcomes in patients with coronary artery disease. This retrospective observational study evaluates the Prognostic Nutritional Index (PNI)-a simple score derived from serum albumin and lymphocyte counts-as an objective measure of nutritional and inflammatory status. The research aims to determine how well preoperative PNI and its postoperative changes can predict complications such as acute kidney injury, myocardial infarction, and sternal wound infections in patients undergoing CABG.

Interventions

DIAGNOSTIC_TESTPrognostic Nutritional Index (PNI)

Calculated using serum albumin (g/L) and total peripheral lymphocyte count.

DIAGNOSTIC_TESTNeutrophil-to-Lymphocyte Ratio (NLR)

Calculated from peripheral blood counts.

DIAGNOSTIC_TESTBody Mass Index (BMI)

Calculated from preoperative weight and height.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

25 Years to 55 Years

Healthy volunteers

Inclusion criteria

* Patients who underwent CABG surgery. * Availability of a signed informed consent form before surgery.

Exclusion criteria

* Other concurrent cardiac surgeries. * Presence of malignancy or systemic inflammatory disorders. * Active infection or autoimmune disorders. * Maintenance on immunosuppressants. * Liver disease. * Files with missing data.

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic Accuracy of the Prognostic Nutritional Index (PNI) in Predicting Post-CABG Complications.	Approximately 30 days (From surgery through the duration of the hospital/ICU stay.)	The Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) used to determine the performance of the PNI score in predicting the occurrence of major postoperative complications.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026