Emergence Agitation
Conditions
Keywords
Emergence agitation, Intravenous dexmedetomidine, Endoscopic sinus surgery, Intravenous lidocaine
Brief summary
The effect of intravenous dexmedetomidine versus intravenous lidocaine on the emergence agitation after endoscopic sinus surgery.
Detailed description
Endoscopic sinus surgery (ESS) is a common operation for patients with chronic rhinosinusitis with nasal polyps (CRSwNP) when medical therapy alone is insufficient . Early recovery from general anesthesia is accompanied by agitation, confusion, disorientation, and violent behavior, which is known as Emergence Agitation (EA). This post-anesthetic issue occurs in the early stages of General Anesthesia (GA) recovery, posing challenges in terms of both patient recovery delay and the complexities associated with assessment and management. The incidence of EA varies, from approximately 0.25% to 90.5%, with age, assessment tool used, definitions, anesthetic techniques, type of surgery, and time of EA assessment during recovery . Because the airway is contaminated with blood and the nasal airway is closed with surgical packs. ENT surgery is linked to a higher incidence of emerging agitation after nasal surgery. Although EA is commonly self-limited and happens within the first 30 min of stay in a postanesthesia care unit (PACU) and also can lead to disconnection of monitoring devices or intravenous catheters, physical damage, falling, increase in the risk of bleeding, and self-extubation . Several pharmacological methods have been used to mitigate EA, including opioid (fentanyl, remifentanil), propofol, benzodiazepine (midazolam), α2- aderenoreceptor agonist (clonidine, dexmedetomidine), and N-methy-d-aspar- tate (NMDA) receptor antagonist (ketamine, magnesium sulfate) administration. Lidocaine is an amino amide-type short-acting local anesthetic (LA). It has a short half-life, and a favorable safety profile, and is therefore the LA of choice for continuous IV administration. Systemic lidocaine has been shown to be an effective adjunct strategy to reduce postoperative pain. Dexmedetomidine is known as a highly selective α (2)-adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic-sparing effects, which causes minimal depression of the respiratory function.
Interventions
DRUGDexmedetomidine
Group (D) recieves Dexmedetomidine bolus 1mcg/kg over 10 minutes before induction of anesthesia followed by continous infusion at 0.4 mcg/kg/h until the end of surgery
DRUGLidocaine
Group (L) recieves IV lidocaine 1.5 mg/kg slowly before induction of anesthesia then lidocaine infusion starts at a rate of 2mg/kg/h
Sponsors
Fayoum University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age : 18-60 * ASA Physical Status I or II * Elective endoscopic sinus surgery under general anesthesia .
Exclusion criteria
* Refusal to participate * Mental retardation or inability to communicate * Allergy to anesthetics or study medications . * Chronic use of beta blockers . * significant hepatic, neurologic, cardiovascular or respiratory disease . * BMI\>35 kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of emergence agitation (EA) . | Immediate after extubation | Incidence of emergence agitation (EA) as measured by Richmond Agitation Sedation Scale (RASS) . |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| heart rate (beats per minute ) | baseline ( preoperative ) | heart rate (beats per minute ) was measured using standard ECG monitoring |
| Mean arterial blood pressure (mmHg) | baseline ( preoperative ) | MAP ( mmHg) was measured using standard non-invasive blood pressure monitoring . |
| Peripheral oxygen saturation (SpO2, %) | baseline ( preoperative ) | Peripheral oxygen saturation (SpO2, %) was measured using pulse oximetry |
| Postoperative pain score | 0, 1 h(hour), 3h, 6h, 12h, 24h postoperatively | Postoperative pain was assessed using the Numeric rating scale (NRS) , ranging from 0 ( no pain ) to 10 ( worst imaginable pain ) |
| Incidence of adverse events | first 24 hours postoperative | Incidence of adverse events including postoperative nausea\&vomiting , allergy , bradycardia (HR\<50) , hypotension (MAP decreases by \>20%) , desaturation ( SpO2\<92%) |
| heart rate (beats per minute) | after 60 minutes ( intraoperative ) | heart rate (beats per minute ) was measured using standard ECG monitoring |
Countries
Egypt
Contacts
CONTACTKhaled E Tolba, MBBCH
CONTACTMohamed A Hamed, MD
PRINCIPAL_INVESTIGATORKhaled E Tolba, MBBCH
Outcome results
None listed