Diabetic Chronic Kidney Disease Patients
Conditions
Brief summary
This observational study will collect clinical and laboratory information from hospitalized patients with chronic kidney disease to identify diabetes mellitus and selected metabolic findings during hospitalization
Detailed description
Hospitalized adult patients with chronic kidney disease will be included in this observational study. Information routinely recorded during hospitalization will be collected. This information will include the presence of diabetes mellitus and laboratory values related to blood glucose levels, electrolyte levels, and acid base balance. No study related interventions will be performed.
Interventions
BEHAVIORALPrimary aim 1. To assess the frequency of diabetes mellitus among hospitalized CKD patients. 2. To evaluate the frequency and types of metabolic abnormalities (e.g., hypoglycemia, diabetic ketoacidosi
Primary aim 1. To assess the frequency of diabetes mellitus among hospitalized CKD patients. 2. To evaluate the frequency and types of metabolic abnormalities (e.g., hypoglycemia, diabetic ketoacidosis/ hyperosmolar states, metabolic acidosis, dyslipidemia, electrolyte imbalance) in diabetic CKD patients. Secondary aim 1\. To evaluate the association between diabetes and diabetes-related metabolic derangements in-hospital adverse outcomes (major cardiovascular events, ICU admission, length of stay, infection rate, need for dialysis and mortality) among hospitalized patients with CKD.
Sponsors
Sohag University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age greater than or equal to 18 years * Known chronic kidney disease, defined as baseline estimated glomerular filtration rate less than 60 milliliters per minute per 1.73 square meters for at least 3 months, or documented chronic kidney disease stage 3 to 5 by prior medical records * Hospitalized for any medical reason * Consent provided
Exclusion criteria
* Acute single episode of reversible acute kidney injury with previously normal renal function (no established chronic kidney disease) * Admission for palliative care or expected survival less than 24 hours * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| In-Hospital Mortality | From admission until hospital discharge, assessed over a 6-month study enrollment period. | Patient death from any cause occurring during the hospitalization period |
| New Requirement for In-Hospital Renal Replacement Therapy | From admission until hospital discharge, assessed over a 6-month study enrollment period. | Initiation of dialysis in a patient who was not receiving renal replacement therapy at the time of hospital admission |
| Incidence of a Major In-Hospital Cardiovascular Composite Event | From admission until hospital discharge, assessed over a 6-month study enrollment period. | A composite outcome defined as the first occurrence of any of the following during the hospitalization: myocardial infarction, stroke, or new-onset heart failure requiring inotropic support or mechanical ventilation |
Countries
Egypt
Contacts
CONTACTMohamed Mahmoud Rashad, Master Degree
CONTACTMahmoud Ibrahim Yousef, Associate Professor
Outcome results
None listed