Metabolic Syndrome Risk Factors
Conditions
Keywords
Antioxidants, Dietary antioxidant index, Metabolic Syndrome risk
Brief summary
Metabolic syndrome (MetS) is a cluster of metabolic disorders characterized by elevated levels of blood glucose, hypertension, dyslipidemia, and abdominal obesity. Globally, it is a major public health concern. International studies have linked higher Dietary Antioxidant Index with reduced risk of MetS, as antioxidants play a role in lowering the risk of MetS by reducing oxidative stress, a key contributor to its pathophysiology. Exploring this link in Pakistan can provide valuable insights for dietary strategies to reduce the risk of MetS.
Detailed description
Background: Metabolic syndrome (MetS) is a cluster of metabolic disorders characterized by elevated levels of blood glucose, hypertension, dyslipidemia, and abdominal obesity. Globally, it is a major public health concern. International studies have linked higher Dietary Antioxidant Index (DAI) scores with reduced risk of MetS, as antioxidants play a role in lowering the risk of MetS by reducing oxidative stress, a key contributor to its pathophysiology. Exploring this link in Pakistan can provide valuable insights for dietary strategies to reduce the risk of MetS. Hypothesis: A dietary intervention aimed at improving Dietary Antioxidant Index (DAI) scores beneficially affects Metabolic Syndrome risk factors among urban adults at risk of developing Metabolic Syndrome. Material and Methods: A single-group pre-post human interventional study will be conducted among at-risk urban adults identified through the NCEP ATP III and WHO criteria. Dietary recalls will be analyzed in NutriSurvey using the Pakistan Food Composition Table, and any missing nutrient values will be supplemented from the Indian Food Composition Table. Nutrient data will be used to calculate the Dietary Antioxidant Index (DAI). Individuals with low DAI will receive dietary intervention. Statistical Analysis: Pre-post changes in DAI and MetS markers will be assessed using paired t-tests, and Pearson's correlation will determine their associations using SPSS 25. Expected Outcomes: The intervention is expected to reduce key Metabolic Syndrome risk factors while increasing individuals' awareness and motivation to adopt healthier behaviors.
Interventions
OTHERAntioxidant-Focused Diet Intervention
This intervention specifically targets the Dietary Antioxidant Index (DAI) by increasing consumption of antioxidant-rich foods such as fruits, vegetables, whole grains, and legumes, while limiting pro-oxidant and ultra-processed foods. Unlike general healthy diet interventions, this study focuses on quantifiable antioxidant intake and its direct association with metabolic syndrome risk in urban adults.
Sponsors
University of Veterinary and Animal Sciences, Lahore - Pakistan
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
This study uses a single-group interventional pre-post design to assess the effect of an antioxidant-rich diet on Dietary Antioxidant Index (DAI) and metabolic syndrome risk. Participants will receive an antioxidant rich dietary intervention, and changes in DAI and metabolic syndrome parameters will be measured before and after the intervention.
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 18-45 years * Metabolic syndrome risk (abdominal obesity \& elevated BP as per NCEP ATP III criteria). * Low fruit \& veg intake (\<5 serv./day) as per WHO. * Willing to follow an intervention * Non-pregnant or lactating * Not diagnosed with malabsorption syndrome or chronic illness
Exclusion criteria
* Individuals \< 18 years or \> 45 years * Not at risk of metabolic syndrome. * Adequate intake of fruits \& veg (≥ 5 serv./day) as per WHO * Not willing * Pregnant or lactating * Diagnosed with malabsorption syndrome or chronic illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Dietary Antioxidant Index (DAI) | Baseline and after 12 weeks of intervention | DAI will be calculated from 24-hour dietary recalls to quantify total antioxidant intake. The primary objective is to assess whether the antioxidant-rich diet increases DAI in participants. |
| Change in Metabolic Syndrome Risk Score | Baseline and after 12 weeks of intervention | A composite metabolic syndrome risk score will be calculated by summing standardized z-scores of waist circumference (cm), fasting blood glucose (mg/dL), systolic blood pressure (mmHg), triglycerides (mg/dL), and inversely weighted HDL-cholesterol (mg/dL) to generate a single continuous measure of overall metabolic syndrome risk. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Body Composition | Baseline and after 12 weeks of intervention | Body composition, including body fat percentage and skeletal muscle mass, will be assessed using InBody analyzer to evaluate changes in body composition. |
Countries
Pakistan
Contacts
CONTACTAnaum Javed, PG
CONTACTQaisar Raza, Ph.D
PRINCIPAL_INVESTIGATORQaisar Raza, Ph.D
UNIVERSITY OF VETERINARY & ANIMAL SCIENCES, LAHORE PAKISTAN.
Outcome results
None listed