Thermal Measurements of the Gut With a Colonoscope Compatible Thermal Probe

Colonoscopic Investigation of the Correlation Between Bowel Wall Inflammation and Luminal Temperature Rise in IBD

Status

Enrolling by invitation

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07352995

Enrollment

Registered

2026-01-20

Start date

2026-03-25

Completion date

2029-12-01

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn Disease, Inflammatory Bowel Diseases, Ulcerative Colitis

Brief summary

The goal of this clinical trial is to use a modified thermal probe to measure temperature rise in the colonic mucosa of participants with inflammatory bowel disease, Crohn's disease, and/or ulcerative colitis. The main question it aims to answer is: Is the thermal probe an effective device to use to detect temperature rise in the colonic mucosa? During the participant's standard of care colonoscopy, the thermal probe will be inserted into the colonoscope. The thermal probe is connected to a temperature transmitter that collects and saves the temperature of the colon in real time.

Interventions

DEVICEFeasibility of using a thermal probe to measure temperature rise in colonic mucosa

10 participants in each arm will be enrolled in this study. All consented participants will receive the same intervention.

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DEVICE_FEASIBILITY

Masking

NONE

Intervention model description

All study participants will get the same intervention

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Participants 18 years or older * Participants undergoing elective colonoscopy * Participants capable of following requirements * Participants capable of providing informed consent * Participants with a diagnosis of IBD, Crohn's disease, and/or ulcerative colitis or participants undergoing colorectal cancer screening

Exclusion criteria

* Participants contraindicated for colonoscopy, including experiencing acute events within the last 6 weeks prior to the colonoscopy (i.e. subjects suffering from a myocardial infarction (heart attack), diagnosis of peritonitis (the inflammation of the membrane lining of the abdominal wall), diagnosis of hemodynamic instability (shock), surgery involving colonic anastomosis (reconnection of the colon), and/or bowel injury (from trauma or surgery) * Participants who are pregnant

Design outcomes

Primary

Measure	Time frame
Ability of thermal probe to collect temperature measurements from colonic mucosa	Thermal measurements are collected during the study procedure and analyzed within one year of collection.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORGuillermo Tearney, M.D., PhD

Massachusetts General Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 21, 2026