DOES LOWER BODY PLYOMETRICS CAUSE RHABDOMYOLYSIS IN FEMALE VOLLEYBALL PLAYERS-AN EXPERIMENTAL STUDY

Effects of Lower Body Plyometric Training on Serum CPK and Creatinine Levels in Collegiate Female Volleyball Players: An Experimental Study

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07352319

Enrollment

Registered

2026-01-20

Start date

2022-01-12

Completion date

2022-10-25

Last updated

2026-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Athletes, Exercise-Induced Muscle Damage, Rhabdomyolysis

Brief summary

Eight-week interventional study to evaluate whether lower-body plyometric training alters serum creatine phosphokinase (CPK) and creatinine levels in female collegiate volleyball players. Sixty participants were randomized to experimental (plyometrics twice weekly) or control (routine volleyball) groups. Blood sampling occurred at baseline; days 2, 4, and 6; and weeks 1, 2, 4, 6, and 8.

Detailed description

Intervention adapted from James & Robert (2015). Experimental group completed progressive lower-body plyometrics twice weekly (Monday/Wednesday) over eight weeks with warm-up and cool-down. Exercises included squat jump; jump to box (30 cm); tuck jump; split squat jump; lateral hurdle jump (50 cm); zigzag jump; single-leg tuck jump; and depth jump (80 cm). Control group continued routine volleyball activities and did not perform low/medium/high-intensity plyometrics. Primary biomarker (serum CPK) assessed via CK-NAC optimized IFCC method; serum creatinine by modified Jaffe's method. Two-way ANOVA with Bonferroni post hoc used. Findings: CPK increased from day 2, peaked day 4, stabilized to week 2, then declined toward baseline by week 8; creatinine remained stable.

Interventions

OTHERplyometric program

Twice-weekly sessions (Mon/Wed) for 8 weeks; exercise menu and dosing per Table 1 (intensity, rest, and jumps/set).

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 25 Years

Healthy volunteers

Yes

Inclusion criteria

Active collegiate female volleyball players * consent to participate * no prior plyometric training program.

Exclusion criteria

* Neuromuscular impairments * recent injuries.

Design outcomes

Primary

Measure	Time frame	Description
Serum CPK (U/L)	Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks	change from baseline at day 2, day 4, week 1, week 2, week 4, week 6, week 8

Secondary

Measure	Time frame	Description
Serum creatinine (mg/dL)	Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks	change from baseline over same time points

Countries

Saudi Arabia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026