Tic Disorders
Conditions
Keywords
Transcranial Magnetic Stimulation
Brief summary
This study aims to establish a novel personalized closed-loop NiBS/TMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations. Additionally, it seeks to elucidate the underlying neural circuit mechanisms, enhance the therapeutic efficacy of TMS in pediatric TDs, and achieve precision neuromodulation for children with TDs.
Interventions
DEVICETranscranial Magnetic Stimulation
Transcranial magnetic stimulation (TMS) will be administered to the child using a ZL-N-010 model device, targeting predefined sites in the prefrontal, bilateral temporal, and parietal lobes.
BEHAVIORALgeneral behavioral therapy
Behavioral interventions include avoiding screen time, parental avoidance of scolding or corporal punishment, and steering clear of activities or emotional stimuli that may exacerbate symptoms.
Sponsors
Shanghai Children's Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
5 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* 1: Children and adolescents aged 5 to 18 years 2: Meets DSM-5 diagnostic criteria for Tic Disorders (TDs) with normal EEG findings 3: No prior treatment received for TDs 4: Full-scale intelligence quotient (FIQ) ≥70 on the Wechsler Intelligence Scale for Children-Revised (WISC-R)
Exclusion criteria
* 1: WISC-R Full-Scale Intelligence Quotient (FIQ) \<70 2: Presence of metal implants in the body ，Non-right-handedness 3: Head movement (HM) \>2mm during fMRI scanning, including both translational movement (TM) and rotational movement (RM) 4: Any other neurological or psychiatric conditions, including but not limited to autism spectrum disorder (ASD), epilepsy, obsessive-compulsive disorder (OCD), etc 5: Previous head trauma ，Neurological diseases ，Major systemic illnesses
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tic Severity | 10 weeks | The severity of the child's clinical tic symptoms assessed via the Yale Global Tic Severity Scale. |
| Changes in brain region activation intensity and resting-state connectivity before and after treatment. | 10 weeks | Based on fMRI imaging, changes in brain region activation intensity (BOLD signals) and resting-state functional connectivity (FC) before and after treatment were compared. |
Countries
China
Contacts
CONTACTJun Ma, M.D.
Outcome results
None listed