Asthma, Mild-to-moderate Asthma, Asthma Control Level
Conditions
Keywords
asthma, asthma control, mild-to-moderate asthma, Thailand, remission, FeNO, blood eosinophil count
Brief summary
The goal of this observational study is to determine the prevalence of remission among adults with mild-to-moderate asthma, as well as the factors associated with remission in Thailand. The main question the study aims to answer is: What is the prevalence of remission among adults with severe asthma in Thailand? Participants will complete a questionnaire on asthma symptoms and undergo pulmonary function testing and a blood test once.
Detailed description
This study is a cross-sectional study. Thai patients aged 18 years or older with mild-to-moderate asthma are included in the study. Participants will complete two questionnaires about asthma control: the Global Initiative for Asthma (GINA) and the Asthma Control Test (ACT), and will perform spirometry, a fractional exhaled nitric oxide (FeNO) test, and blood eosinophil counts (BEC). GINA and ACT are questionnaires used to assess the level of asthma control.
Interventions
GINA and ACT are questionnaires used to assess the level of asthma control.
OTHERSpirometry
Spirometry is a tool used to assess pulmonary function.
FeNO is a tool used to assess eosinophilic airway inflammation and asthma remission.
BEC is a tool used to assess eosinophilic inflammation and asthma remission.
Sponsors
Thammasat University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* mild-to-moderate asthma * age 18 years or older
Exclusion criteria
* inability to perform spirometry or fractional exhaled nitric oxide (FeNO) test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence rate of mild-to-moderate asthma remission | An average of 1 year | Prevalence rate of mild-to-moderate asthma remission (%) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Type 2 airway inflammation in patients with mild-to-moderate asthma | At baseline and at 12 months | Type 2 airway inflammation is assessed using fractional exhaled nitric oxide (FeNO, ppb). |
| Asthma control in patients with mild-to-moderate asthma | At baseline and at 12 months | Rate of patients with well-controlled asthma. Well-controlled asthma is defined as an Asthma Control Test (ACT) score of 20 or higher. |
| Airway obstruction in patients with mild-to-moderate asthma | At baseline and at 12 months | Airway obstruction is assessed using FEV1/FVC ratio on spirometry. |
| Severity of aiway obstruction in patients with mild-to-moderate asthma | At baseline and at 12 months | The severity of aiway obstruction is assessed using FEV1 % predicted on spirometry. |
| Eosinophil airway inflammation in patients with mild-to-moderate asthma | At baseline and at 12 months | Eosinophil airway inflammation is assessed using blood eosinophil count (cells/µL). |
Countries
Thailand
Contacts
CONTACTNarongkorn Saiphoklang, MD
CONTACTSirashat Hanvivattanakul, MD
PRINCIPAL_INVESTIGATORNarongkorn Saiphoklang, MD
Thammasat University Faculty of Medicine
Outcome results
None listed