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Effectiveness of Large Language Model-Based Chatbot Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates

A Study on the Effectiveness of Large Language Model-Based Chatbot Interventions Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07351604
Enrollment
18000
Registered
2026-01-20
Start date
2026-04-01
Completion date
2027-12-31
Last updated
2026-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HPV Vaccination Intention, HPV Vaccination Rates, HPV Vaccine Awareness

Keywords

HPV vaccine, chatbot, Large language model, AI, HPV vaccination

Brief summary

This is an interventional study targeting female university students. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates. The secondary objectives are to evaluate the effectiveness in improving vaccine awareness and vaccination intention. All participants will be enrolled and randomly assigned to four groups: (1) vaccine chatbot plus scientific videos, (2) vaccine chatbot only, (3) scientific videos only, and (4) a control group (no intervention). The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. The scientific videos will cover content related to HPV vaccine safety, efficacy, and other relevant information. The study will compare changes in HPV vaccine awareness, vaccination intention, and vaccination behavior between the intervention groups and the control group after the intervention to evaluate whether the three intervention strategies enhance HPV vaccine awareness, vaccination intention, and vaccination uptake.

Interventions

Provide scientific videos related to HPV vaccine

Provide vaccine chatbot to answer HPV vaccine questions

Sponsors

Xiamen University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Female university students. 2. Possess an electronic device with QR code scanning capability. 3. Female university students have no contraindications to HPV vaccination. 4. No mental disorders or visual/reading impairments; able to cooperate with and implement the corresponding intervention activities. 5. Have provided informed consent and are willing to participate in the study.

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
HPV vaccination rates for female university students in all groups before and after the interventionBaseline and two monthsWhether female university students get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system

Secondary

MeasureTime frameDescription
HPV vaccine awareness for eligible female university students in all groups before and after the interventionBaseline and two weeksA questionnaire consisting of 11 questions related to HPV vaccines will be used to investigate the awareness of HPV vaccines.Total knowledge score is calculated based on the number of questions answered correctly by the participants and the higher scores mean a better outcome.
HPV vaccination intention for eligible female university students in all groups before and after the interventionBaseline and two weeksFemale university students' willingness to vaccinate themselves, measured using a five-point Likert scale from "not willing at all" to "strongly willing"

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 1, 2026