Noninvasive Real-Time Arterial Waveform Monitoring for Cardiovascular Disease Assessment

A Study on Noninvasive Real-Time Arterial Pressure Waveform Analysis for the Detection and Evaluation of Cardiovascular Diseases

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07350629

Enrollment

Registered

2026-01-20

Start date

2025-12-26

Completion date

2026-02-01

Last updated

2026-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Regurgitation Disease, Aortic Stenosis Disease, Healthy Subjects

Brief summary

The goal of this observational study is to learn whether noninvasive real-time arterial waveform monitoring can be used to assess cardiovascular diseases in adults. The main question it aims to answer is: Can photoacoustic imaging accurately capture arterial waveforms from patients' fingers? Can features extracted from the arterial waveforms reflect the type and severity of cardiovascular diseases? Participants will be asked to place their fingers into the imaging device, where their finger arterial pulse information will be noninvasively recorded.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 18-80 years * Able to provide informed consent * For AR group: clinically diagnosed aortic regurgitation * For AS group: clinically diagnosed aortic stenosis * For healthy controls: no history of cardiovascular disease * Able to undergo finger arterial waveform measurement

Exclusion criteria

* History of recent cardiac surgery or intervention (\<6 months) * Hand disorders affecting finger mobility (e.g., arthritis) * Pregnant or breastfeeding women * Participation in other studies affecting arterial waveform * Unable to understand or comply with study procedures

Design outcomes

Primary

Measure	Time frame	Description
Evaluation of the state of aortic regurgitation and aortic stenosis by photoacoustic tomography	At enrollment (single time point)	To determine the feasibility of using photoacoustic tomography to differentiate aortic regurgitation and aortic stenosis based on arterial waveform measurements.

Secondary

Measure	Time frame	Description
Rise time of photoaocustic arterial waveform	At enrollment (single time point)	To determine the systolic upstroke rise time of arterial waveforms using photoacoustic tomography
Decay time of photoaocustic arterial waveform	At enrollment (single time point)	To determine the diastolic decay time of arterial waveforms using photoacoustic tomography
Dicrotic notch time of photoaocustic arterial waveform	At enrollment (single time point)	To determine the dicrotic notch time of arterial waveforms using photoacoustic tomography

Countries

China

Outcome results