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Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF

Evaluating the Impact of Pre-Hospital Angiotensin Receptor-Neprilysin Inhibitor (ARNI) Therapy on Short-Term Clinical Outcomes in Heart Failure Patients With Reduced Ejection Fraction: A Comparative Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07347925
Enrollment
140
Registered
2026-01-16
Start date
2026-01-10
Completion date
2026-05-01
Last updated
2026-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Keywords

Heart Failure, NYHA class, Sacubitril/Valsartan, Chronic kidney disease

Brief summary

This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before hospital admission affects short-term health outcomes. The study will compare two groups of participants: those who were already taking ARNI before coming to the hospital and those who were not. Information will be collected from medical records during the hospital stay, including heart-related events, kidney-related events, and how long participants stay in the hospital. Some participants will also be followed for a short period after discharge. This study may help improve understanding of outcomes associated with ARNI use in people with heart failure in routine clinical care.

Interventions

OTHERNo prehospital ARNI use

Participants who were not using ARNI therapy before hospital admission

OTHERPrehospital ARNI use

Participants who were using ARNI therapy before hospital admission

Sponsors

Future University in Egypt
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* \>= 18 years, male or female EF \<40%

Exclusion criteria

* EF\>40% Pregnancy or breastfeeding

Design outcomes

Primary

MeasureTime frame
In-hospital cardiac and renal events3 months

Secondary

MeasureTime frame
NYHA classification3 months

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026