Aphasia
Conditions
Brief summary
This clinical trial aims to study whether dual-target transcranial alternating current stimulation (tACS) applied to the auditory and motor brain region can improve repetition disorder in people with stroke, and to evaluate the safety of tACS. The main goals are to answer the following questions: 1. Can dual-tACS stimulation of the auditory and motor brain area improve repetition functions in people with aphasia after stroke? 2. Can it improve the integration of auditory information and speech motor control during communication? Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better outcomes in aphasia patients. Participants will: 1. Receive one extra 20-minute session of either real or sham tACS each day for 10 days 2. Attend clinic visits before and after 10-days stimulation for clinical assessments(WAB) and fNIRS recording related brain activity
Interventions
BEHAVIORALspeech training
speech training(especially repetition training) synchronized with tACS stimulation
OTHERreal tACS
dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes.
OTHERsham tACS
except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group.
Sponsors
Ke Dong, MD
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months; * Age ranging from 30 to 80 years old; * Native language is Mandarin or Cantonese; * Right-handed; * Diagnosed with aphasia by the Western Aphasia Battery (WAB) scale; * Able to cooperate in completing the speech repetition test; * Normal hearing.
Exclusion criteria
* Currently receiving non-invasive brain stimulation treatment; * Lesions involving the Broca or STG brain regions; * History of epilepsy, mental illness,or other neurological or mental disorders; * Any contraindications for transcranial electrical stimulation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Western Aphasia Battery (WAB) score | Baseline and 10-days | Western Aphasia Battery (WAB) score：0-100，higher score means better language function |
Countries
China
Outcome results
None listed