Adult
Conditions
Brief summary
Mining the gut microbiota of adults for health-relevant microbial signatures.
Detailed description
This study is a community-based, observational cross-sectional investigation, enrolling 1,530 middle-aged and elderly volunteers. Data were collected through a systematic, multi-dimensional assessment, which included: Biospecimen Collection: Blood, urine, and stool samples were obtained from the volunteers. Physical and Imaging Examinations: Procedures included anthropometric measurements, vital sign monitoring, oral examinations, electrocardiograms, physical examinations of key organs, and abdominal ultrasonography. Psychological and Cognitive Assessments: Standardized scales were administered to assess anxiety/depression and memory function. All clinical and questionnaire data were processed through standardized procedures, forming a comprehensive health database for subsequent analysis.
Interventions
OTHERObservational, non-interventional study.
Observational, non-interventional study.
Sponsors
Huzhou Central Hospital
Zhujiang Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
30 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
： * Community-dwelling adults aged 30 to 95 years. * Individuals who underwent an annual health examination at the Health Management Center of Huzhou Central Hospital during the specified time period. * Ability to comprehend the study content and voluntarily provide signed informed consent. * Willingness and ability to provide the required biospecimens (blood, urine, stool).
Exclusion criteria
* Concurrent participation in another interventional clinical trial that is likely to interfere with the results of this study. * Voluntary withdrawal from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of Health-Relevant Signatures in Adults | Baseline | Primary Outcome Measure 1)Change in standard laboratory parameters from baseline:Changes in routine laboratory parameters measured in blood, urine, and stool samples, including complete blood count and standard serum biochemistry panels.Unit of Measure: Various laboratory units (e.g., g/L, U/L, mmol/L); 2) Change in anthropometric measurements from baseline: Anthropometric measurements including body weight (kg), height (m), and body mass index (BMI, kg/m²).Unit of Measure:kg, m, kg/m²; 3) Alcohol consumption status: Alcohol consumption status assessed by self- report, categorized as current drinker or non-drinker at enrollment.Unit of Measure:Categorical (yes/no); 4) Hospital Anxiety and Depression Scale (HADS) scores: Anxiety and depression symptom severity assessed using the Hospital Anxiety and Depression Scale, including anxiety and depression subscale scores.Unit of Measure:Score on a standardized scale. |
Countries
China
Outcome results
None listed