A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)

Individualized Physiotherapy Addressing Patient-Specific Deficits in Amyotrophic Lateral Sclerosis Compared to Usual Care Physiotherapy: A Prospective, Pseudorandomized, Controlled, Interventional Study

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07341984

Acronym

Train ALS

Enrollment

Registered

2026-01-15

Start date

2025-12-16

Completion date

2028-12-15

Last updated

2026-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amyotrophic Lateral Sclerosis

Brief summary

This study investigates whether an individualized physiotherapy program, tailored to each patient's specific motor deficits, can better support physical function compared with usual care physiotherapy in people with ALS. The individualized program is guided by diagnostic assessments using a robotic leg press system, which helps identify strengths and weaknesses in muscle function and movement control. Participants will receive either individualized physiotherapy or standard physiotherapy and will be followed for 12 months. The aim of the study is to improve physiotherapy strategies for people with ALS in a safe and patient-centered manner.

Interventions

OTHERIndividualized Physiotherapy

see above

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* diagnosis of clinically probable, probable laboratory-supported, or definite ALS (revised El Escorial criteria) or upper motor neuron only (OPM classification \[onset, propagation, motoneuron involvement\]) * age ≥18 years; ability to understand study information and provide written informed consent * Willingness and ability to perform individualized exercise according to the study protocol (approximately three to five sessions of 30 minutes per week) for the duration of the intervention period * Individuals of all sexes and gender identities are eligible for inclusion

Exclusion criteria

* pregnancy, tracheostomy, continuous assisted ventilation, or other significant non-ALS pulmonary disease * other neurodegenerative or neuromuscular conditions that may confound assessments * concomitant life-threatening disease or impairment interfering with functional assessment

Design outcomes

Primary

Measure	Time frame	Description
Climbing stairs (ALSFRS-R [amyotrophic lateral sclerosis functional rating scale - revised] - item 9: score range 0 to 4 with 4 indicating normal function)	6 months	funcitonal

Countries

Switzerland

Contacts

Primary ContactCharlotte Vogt

charlotte.vogt@h-och.ch0041714943581

Backup ContactOleksandra Hoptar

oleksandra.hoptart@h-och.ch0041714943581

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026