Deceased Donor Kidney Transplant, Kidney Failure, Kidney Transplant
Conditions
Keywords
kidney transplantation, allocation, deceased donor, organ utilization
Brief summary
The persistent imbalance between kidney transplant demand and organ availability remains a major global challenge. Optimizing the utilization of kidneys from deceased donors is a critical strategy to expand the donor pool and increase access to transplantation. Previous studies have demonstrated substantial international differences in kidney acceptance and discard practices, with significant potential gains in allograft life-years through optimized utilization. However, major changes in allocation policies, donor characteristics, preservation technologies, and global events such as the COVID-19 pandemic may have altered contemporary utilization patterns. This study aims to characterize international trends in deceased donor kidney utilization, compare allograft survival across countries, and estimate potential transplantable allograft life-years gained through improved utilization practices.
Detailed description
Substantial imbalance between organ demand and availability remains a major challenge in kidney transplantation worldwide. Therefore, expanding the donor pool is a critical priority, and a key strategy is optimizing the utilization of organs from deceased donors. Our previous study (PMID: 31449299) demonstrated significant disparities in kidney acceptance and discard rates between US and France, with US discarding kidneys at nearly twice the rate of France. Simulation modeling suggested that adopting more aggressive, French-based acceptance practices could have prevented 17 435 discarded kidneys in the US over ten years, generating an additional 132 445 allograft life-years. Since that period the transplantation landscape has evolved substantially. Key developments include major policy reforms such as the 2014 US Kidney Allocation System redesign, increased use of advanced preservation technologies, expanding acceptance of hepatitis C-positive donor organs, substantial growth in donation after circulatory death (DCD), and global disruptions in transplant activity caused by the COVID-19 pandemic. The impact of these developments on current utilization practices and international disparities remains unknown. Contemporary patterns of deceased donor kidney utilization and discard rates across different allocation systems have not yet been characterized. This study aims to: 1. Characterize international patterns and temporal trends in deceased donor kidney utilization and discard rates from 2010 to 2025. 2. Compare allograft survival across countries and donor risk profiles. 3. Quantify potential transplantable allograft life-years gained through optimized utilization practices.
Interventions
None listed
Sponsors
Vanderbilt University Medical Center
Paris Translational Research Center for Organ Transplantation
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* All consecutive kidneys recovered for the purpose of transplantation from donors deceased from brain death or circulatory death between January 1, 2010 and December 31, 2025
Exclusion criteria
* Kidneys offered to transplant centers but never recovered * Living renal transplants * Multiorgan transplant recipients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Kidney allograft discard | Day 0 | defined as kidneys recovered for transplantation but not transplanted. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Allograft failure | up to 15 years | defined as return to dialysis and/or re-transplantation. |
| Estimated additional allograft life-years achievable | up to 15 years | through adoption of best practice utilization patterns (simulation based). |
Countries
France, United States
Outcome results
None listed