Type 1 Diabetes (T1D)
Conditions
Keywords
exercise, heat
Brief summary
A randomised, crossover, counterbalanced repeated measures study will be conducted to examine the effect of acute heat exposure on rate of change in blood glucose concentration during 40 minutes of moderate-intensity exercise and for 30 minutes after exercise. Participants will complete two experimental conditions during two separate laboratory visits, with the order of conditions randomised. One condition will be a temperate condition of 20°C with 50% relative humidity (Temperate), the other will be 40°C with 50% relative humidity (Heat). Visits will be identical, including time of day, except for the condition. Visits will be separated by 24h. Testing will take place in the laboratories of the Research Institute for Sport and Exercise Sciences at Liverpool John Moores University.
Interventions
BEHAVIORALExercise
exercise in the heat or temperate conditions
Sponsors
Liverpool John Moores University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* T1D diagnosis more than 1 years ago (to ensure participants are out of the honeymoon period) * Using insulin therapy with multiple daily injections (MDI), insulin pump (pump), or hybrid closed-loop (HCL) o If using a HCL system have experience of using a pre-programmed basal rate in manual mode during exercise * Aged 18-65 years * Regularly engaged in endurance exercise (training at least twice per week for ≥30 minutes per session)
Exclusion criteria
* Pregnancy * \<6 months postpartum or stopped breastfeeding \<1 month before recruitment * Existing cerebrovascular or cardiovascular disease * Significant history of hyperglycaemia (HbA1c \>85 mmol/mol) * History of severe hypoglycaemia requiring third party assistance within the last 3 months * Body weight \<36.5kg * Difficulty swallowing tablets * Appointment for an MRI test that cannot be rescheduled * Obstructive gastrointestinal disease * History of gastrointestinal surgery * Have an implanted medical device
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood glucose | Baseline pre exercise to end of exercise (40 minutes) | change in blood glucose concentration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skin temperature | Baseline pre exercise to end of exercise (40 minutes) | change in skin temperature |
| Free fatty acids | Baseline pre exercise to end of exercise (40 minutes) | change free fatty acid concentration |
| insulin | Baseline pre exercise to end of exercise (40 minutes) | Change in insulin concentration |
| glucagon | Baseline pre exercise to end of exercise (40 minutes) | change in glucagon concentration |
| Core temperature | Baseline pre exercise to end of exercise (40 minutes) | change in core temperature |
| norepinephrine | Baseline pre exercise to end of exercise (40 minutes) | change in norepinephrine concentration |
| cortisol | Baseline pre exercise to end of exercise (40 minutes) | change in cortisol concentration |
| Growth hormone | Baseline pre exercise to end of exercise (40 minutes) | change in Growth hormone concentration |
| lactate | Baseline pre exercise to end of exercise (40 minutes) | change in lactate concentration |
| epinephrine | Baseline pre exercise to end of exercise (40 minutes) | change in epinephrine concentration |
Countries
United Kingdom
Contacts
Primary ContactMatthew Cocks, PhD
Outcome results
None listed