Fertility Outcomes of Ovarian Tissue Cryopreservation

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07339995

Enrollment

100

Registered

2026-01-14

Start date

2026-01-15

Completion date

2032-01-14

Last updated

2026-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neoplasms

Brief summary

With the advancement of assisted reproductive technology, more young cancer patients can consider having children. Ovaries and testes are important reproductive organs, and drugs, diseases, chemotherapy, and radiotherapy can all damage them. Reproductive preservation technology aims to protect patients whose reproductive ability has been damaged due to gonadotoxic drug therapy. Women can preserve their reproductive ability by freezing ovarian tissue cryopreservation so that they can have children in the future. Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital will be invited to participate in the study. Here, we aim to evaluate the outcomes after ovarian tissue cryopreservation.

Interventions

OTHEROvarian tissue freezing and subsequent auto-transplantation after thawing

Removal of the ovarian tissue will be retrieved via laparoscopic surgery under general anesthesia. The ovarian cortical tissue obtained will be transferred on ice to the laboratory for cryopreservation. After medical treatment, if the patient would like to start a family but has experienced premature ovarian failure, she will have ovarian tissue auto-transplantation after thawing.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

0 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Patients aged from 0-18 years old and diagnosed with cancer * Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital * For patients under 18 years old, parents/legal guardians will be asked to further sign the consent for them.

Exclusion criteria

* Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay) * Male patients

Design outcomes

Primary

Measure	Time frame	Description
Surgical complications	15 years	Surgical complications after ovarian tissue transplantation
Pregnancy rate	15 years	Pregnancy rate after ovarian tissue transplantation

Contacts

Primary ContactElaine Ng

elaineng@cuhk.edu.hk35052745

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026