Fluid Balance in Acute Kidney Injury in Critically Ill Patients

Fluid Balance During Early Hours of Acute Kidney Injury in Critically Ill Patients

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07338734

Enrollment

120

Registered

2026-01-14

Start date

2026-01-31

Completion date

2027-02-28

Last updated

2026-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Critically Ill, Critically Ill Acute Kidney Injury, Fluid Balance

Keywords

Fluid Balance, acute kidney injury, AKI, critically ill, KDIGO criteria

Brief summary

This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults. Patients without AKI at entry will have fluids tracked hourly via charts, weights, and labs to assess AKI risk by KDIGO criteria within 7 days. Findings may guide better fluid management to lower AKI rates.

Detailed description

This prospective observational cohort study at Assiut University Hospital ICU investigates the association between fluid balance in the first 48 hours of admission and acute kidney injury (AKI) development. Critically ill adults (≥18 years) without AKI at baseline will undergo routine monitoring: hourly fluid intake/output (IV fluids, blood products, urine, drains, insensible losses), daily weights, serial labs (SCr, BUN, electrolytes, albumin, CRP), and clinical/hemodynamic assessments. AKI is defined/staged by KDIGO criteria within 7 days. Sample size is 120 (Epi-Info calculated, 38.4% expected AKI incidence). Data analysis will examine if positive/negative balances predict AKI incidence, severity, RRT need, ICU stay, and 28-day mortality, using AKI-FB risk score. No interventions; standard care only.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Adults aged 18 years or older admitted to the ICU. * Patients with no AKI at ICU admission. * AKI secondary to (prerenal cause-renal and post renal with manifestation of hypovolemia)-postoperative settings-On top of CKD up to Stage 111b-Compansated heart failure with indication of fluid therapy

Exclusion criteria

* Patients with pre-existing end-stage renal disease requiring dialysis. * Patients with known chronic kidney disease stage 4 or higher. * ICU readmissions during the same hospitalization. * Patients who received renal replacement therapy before ICU admission * Patients with AKI with manifestation of over load as pulmonary edema- pulmonary embolism-Acute decompensated heart failure

Design outcomes

Primary

Measure	Time frame	Description
Incidence of Acute Kidney Injury (AKI)	Within 7 days after ICU admission	Development of AKI defined by KDIGO criteria (increase in serum creatinine by ≥0.3 mg/dL within 48 hours or ≥1.5 times baseline within 7 days, or urine output \<0.5 mL/kg/h for 6 hours).

Secondary

Measure	Time frame	Description
AKI Stage by KDIGO Criteria	Within 7 days after ICU admission	Worst stage of AKI (Stage 1: SCr 1.5-2.9x baseline or UO \<0.5 mL/kg/h ≥6h; Stage 2: SCr 3-5.9x or UO \<0.5 mL/kg/h ≥12h; Stage 3: SCr ≥6x or ≥4.0 mg/dL or RIFLE F/ESRD, UO \<0.3 mL/kg/h ≥24h or anuria ≥12h).

Outcome results