Parvovirus B19 Infection, Pregnancy
Conditions
Brief summary
The goal of this observational study is to define the rate of intrauterine parvovirus B19 infection and fetal/newborn complications after parvovirus B19 infection of pregnant women. Secondary objectives are risk factors, pregnancy outcomes, long-term sequelae and efficacy of the management interventions.
Interventions
OTHERCollection of clinical data.
Observational study
Sponsors
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
ASST Fatebenefratelli Sacco
Fondazione IRCCS San Gerardo dei Tintori
Asst Degli Spedali Civili Di Brescia
Fondazione IRCCS Policlinico San Matteo di Pavia
Study design
Observational model
CASE_ONLY
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Pregnant women \>18 years with parvovirus B19 infection and their neonates.
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of fetuses/newborns with intrauterine B19V infection. | From diagnosis of parvovirus B19 infection in pregnancy to 24/48 hours of life of the newborn. |
| Percentage of fetuses/newborns with complications due to B19V intrauterine infection. | From diagnosis of parvovirus B19 infection in pregnancy to 24/48 hours of life of the newborn. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of fetuses receiving intrauterine transfusion. | From diagnosis of parvovirus B19 infection in pregnancy to delivery. | — |
| Percentage of women with symptomatic B19V infection. | At diagnosis of parvovirus B19 infection in pregnancy | — |
| Percentage of infants with neurologic abnormalities. | From birth to 2 years of life. | — |
| Percentage of newborns with B19V disease. | From diagnosis of parvovirus B19 infection in pregnancy to 20/30 days of life of the newborn. | The following signs/symptoms will be considered: anemia, paleness, petechiae, purpura, icterus, hepato-splenomegaly, ascites, hydrops, pleural effusion, pericardial effusion, neurologic abnormalities. |
| Percentage of fetuses with B19V disease. | From diagnosis of parvovirus B19 infection in pregnancy to delivery. | The following findings will be considered: anemia, hydrops, ascites, pericardial effusion, pleural effusion, subcutaneus oedema, cardiomegaly, placental thickening, cerebral abnormalities, growth retardation. |
Countries
Italy
Contacts
Primary ContactDaniele Lilleri
Outcome results
None listed