Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07335692

Acronym

DYNAPATH-LB

Enrollment

Registered

2026-01-13

Start date

2025-06-02

Completion date

2026-06-02

Last updated

2026-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lewy Body Disease

Keywords

Lewy Body Disease, Neurodegenerative disorder

Brief summary

Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood. The usual diagnostic criteria for LBD have excellent specificity but poor sensitivity. In particular, we lack paraclinical tests that can make a significant contribution. LBD patients may exhibit abnormalities in brain activity dynamics, which can be detected by EEG and may be linked to neuronal dysfunctions specific to the disease. The objective of this study is twofold: first, to assess the validity of this observation, that is, to confirm that the observed phenomenon is indeed linked to the pathophysiology of LBD, and second, to clarify the nature of these abnormalities by exploring the brain dynamics of LBD patients in greater detail.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult subjects (≥18 years old). * Subject who participated in the Alpha-Lewy-MA cohort and underwent RT-QuIC analysis. * Subject who underwent a standard EEG examination at HUS between January 1, 2012, and January 1, 2020.

Exclusion criteria

\- Subject who expressed opposition to participating in the study.

Design outcomes

Primary

Measure	Time frame	Description
Parameter θ of dynamic fluidity of brain activity	Up to 12 months	Parameter θ of dynamic fluidity of brain activity (quantifying the system's ability to move away from its current configuration) θ is used to measure something specific in the brain: how flexible its activity is. Quantifying the system's ability to move away from its current configuration: * In plain words, θ tells us how much the brain can change from its current state. * High θ → brain is very flexible, can switch between states easily. * Low θ → brain is rigid, stays in the same pattern longer.

Countries

France

Contacts

Primary ContactLudovic DORMEGNY-JEANJEAN, MD

ludovic.jeanjean@chru-strasbourg.fr33 3 88 11 69 21

Outcome results