RCT - Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy

Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy

Status

Enrolling by invitation

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07335432

Acronym

Vit C in TAH

Enrollment

Registered

2026-01-13

Start date

2024-09-01

Completion date

2026-07-31

Last updated

2026-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenomyosis of Uterus, Myoma;Uterus

Keywords

Vitamin C, Total abdominal hysterectomy, Blood loss

Brief summary

Intervention Group: Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision. Control Group: Received two doses of a normal saline intravenously (IV) at the exact same times. The primary outcome was to compare intraoperative blood loss between patients who received intravenous Vitamin C and those who did not, following an abdominal hysterectomy under general anesthesia. Intraoperative estimated blood loss (EBL) was meticulously quantified by weighing surgical gauze and measuring suction canister volumes. The secondary outcomes were to evaluate the potential benefits of Vitamin C administration, including: * Reduction in the decline of hematocrit levels after surgery. * Reduction of the length of hospital stay

Interventions

DIETARY_SUPPLEMENTVitamin C (Ascorbic Acid)

Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Female patients who underwent total abdominal hysterectomy * No bleeding tendency. * No history of anticoagulant or thrombolytic drug use * No contraindications to vitamin C supplementation

Exclusion criteria

* Inability to communicate in the Thai language. * Underwent total abdominal hysterectomy due to gynecologic malignancy. * Required emergency total abdominal hysterectomy. * History of vitamin C supplementation within 2 weeks prior to surgery. * History of smoking. * Previous abdominal surgery, such as bowel surgery, cesarean section

Design outcomes

Primary

Measure	Time frame
Intraoperative estimate blood loss	intraoperative

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026