Healthy Adult Male, Runners
Conditions
Brief summary
Muscle fatigue caused by physical training is understood as a condition related to the inability to maintain action potential, derived from the alteration in skeletal muscle homeostasis. In long-distance recreational runners, prolonged physical work is performed while maintaining the level of intensity, where a level of fatigue intervenes, which overlaps and generates tiredness to execute the movement continuously. In the last 10 years, sports supplementation has been explored as an aid to increase physical performance, improve muscle recovery and prevent sports injuries.
Detailed description
Objective: To analyze the effects of an 8-week training program (TP) with vitamin D and branched-chain amino acids (BCAA) supplementation on physical performance and biomarkers of muscle fatigue in long-distance recreational runners. Materials and methods: An 8-week randomized controlled clinical trial. Participants will be 64 men aged 25 to 44 years, distributed into 4 intervention groups. Group A: Training + BCAA + Vitamin D. Group B: Training + BCAA + Placebo. Group C: Training + Vitamin D + Placebo. Group D: Training + Placebo + Placebo. Biomarkers of muscle fatigue Interleukin 6 (L-6), Creatine Kinase (CK), Lactate (Lact), Testosterone and Cortisol ratio and serum vitamin D (25(OH)D) and physical performance will be assessed by estimating Maximal oxygen consumption (VO2max) and (Maximal aerobic speed) MAS.
Interventions
OTHERTraining program
Aerobic training program (60-90% of maximum aerobic speed)
DIETARY_SUPPLEMENTBranched-Chain Amino Acids
Branched-chain amino acids (5 gr/day)
DIETARY_SUPPLEMENTVitamin D
Vitamin D (1000 IU/day)
OTHERPlacebo 1
Placebo 1 (5gr/day)
OTHERPlacebo 2
Placebo 2 (1 tablet/day)
Sponsors
Claudia Ivette Gamboa Gomez
Fabian Rojas Larios
Pedro Julian Flores Moreno
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Masking description
The research is categorized as double-blind parallel groups, the study subjects will be blinded, by not recognizing that they are under supplementation and secondly the principal investigator will also be unaware of the assigned treatment.
Intervention model description
In clinical trial types based on their methodology, this protocol is considered a randomized controlled clinical trial. Based on the behavior of its groups, the research is categorized as a parallel group.
Eligibility
Sex/Gender
MALE
Age
25 Years to 44 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 25 to 44 * Men * Agree to participate in the study * Sign a consent form * Experience in long-distance running
Exclusion criteria
* Have a previous diagnosis of liver disease, asthma, hypertension, diabetes, cancer, anemia * Have a previous diagnosis of a neurological disorder (Alzheimer's disease, Parkinson's disease, epilepsy) * Have a musculoskeletal disability * Be on medication or supplementation * Hypervitaminosis D (\>100 ng/mL) * Be on a structured training program * Use anabolic steroids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in lactate levels compared to the placebo group | 8 weeks | mMol/L |
| Changes in interleukin-6 levels compared to the placebo group | 8 weeks | pg/ml |
| Changes in cratine kinase levels compared to the placebo group | 8 weeks | U/L |
| Changes in testosterone cortisol ratio compared to the placebo group | 8 weeks | mcg/dL |
| Changes in maximal aerobic speed compared to the placebo group | 8 weeks | km/h |
| Changes in maximal oxygen consumption compared to the placebo group | 8 weeks | ml.O2.kg/min |
Countries
Mexico
Contacts
Primary ContactMaría Zepeda Fuentes, Master of Medical Sciences
Outcome results
None listed