Acute Kidney Injury, Sepsis-Related Mortality
Conditions
Brief summary
Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection and remains a leading cause of morbidity and mortality in intensive care units. Early identification of patients at high risk for adverse outcomes is essential for timely intervention and improved prognosis. This prospective, single-center, non-interventional study aims to evaluate the predictive value of the combined use of the blood uric acid/albumin ratio (UAR) and serum lactate levels in patients aged 65 years and older who are admitted to the intensive care unit with a diagnosis of sepsis according to SEPSIS-3 criteria. Patients without acute kidney injury at admission and with at least 24 hours of intensive care follow-up will be included. The primary outcome is the development of acute kidney injury within the first 7 days of ICU admission according to KDIGO criteria. Secondary outcomes include vasopressor requirement during ICU stay, changes in serum lactate levels over the first 24 hours, and 28-day mortality. The study seeks to determine whether the combination of UAR and lactate levels can serve as an easily accessible and clinically applicable biomarker to predict adverse outcomes and support prognostic assessment and treatment strategies in sepsis patients.
Interventions
OTHERNon-interventional / Observational Study
This is a non-interventional, observational study. No diagnostic or therapeutic intervention will be applied beyond routine clinical care. Blood uric acid, albumin, and serum lactate levels measured as part of standard intensive care management will be recorded at admission, and lactate levels will be reassessed at 24 hours. Patients will be followed prospectively during their intensive care stay to evaluate the development of acute kidney injury, vasopressor requirement, and 28-day mortality.
Sponsors
Istinye University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients aged 65 years and older * Diagnosis of sepsis according to SEPSIS-3 criteria * Admission to the intensive care unit * No acute kidney injury at admission according to KDIGO classification * Measurement of serum uric acid, albumin, and lactate levels at ICU admission * SOFA score calculated at ICU admission * ICU follow-up of at least 24 hours
Exclusion criteria
* Age under 65 years * Uncompensated or decompensated chronic liver disease (e.g., Child-Pugh class C) * Chronic kidney disease stage 4 or 5 (eGFR \<30 mL/min/1.73 m²) * Presence of acute kidney injury at admission according to KDIGO criteria * Active malignancy or receipt of active cancer treatment within the last 6 months * Missing or incomplete clinical/laboratory data * ICU follow-up less than 24 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Development of Acute Kidney Injury (AKI) | Within the first 7 days following intensive care unit admission | Occurrence of acute kidney injury defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria in patients with sepsis admitted to the intensive care unit. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactİLKE DOLĞUN
Outcome results
None listed