Female Infertility
Conditions
Keywords
ICSI, Follicular size, Oocyte Retrieval, Oocyte yield, assisted reproduction
Brief summary
This study uses number and size of ovarian follicles on the day of ovulation trigger as key determinants for oocytes yield to optimize outcomes in IVF and ICSI Protocols
Detailed description
Accurate prediction of oocyte yield is a key factor in optimizing outcomes of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles. Follicle number and follicle diameter measured on the day of ovulation trigger are known to be strongly associated with oocyte retrieval and oocyte maturity. Larger follicles are more likely to yield mature (metaphase-II) oocytes, while smaller follicles contribute less consistently to oocyte yield. Despite the established association between follicular size and oocyte maturity, there is currently no standardized clinical model that estimates the minimum expected number of retrieved oocytes based on the distribution of follicle diameters on the trigger day. Most existing studies focus on average outcomes rather than providing a practical tool to estimate the lowest anticipated oocyte yield for individual patients. This study aims to estimate the minimum number of oocytes retrieved based on the number and diameter of ovarian follicles measured on the day of ovulation trigger. By developing a predictive approach based on follicular size distribution, this study seeks to support clinical decision-making, optimize trigger timing, and improve patient counseling regarding realistic expectations of oocyte yield.
Interventions
None listed
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* women aged 18 to 35 years undergoing ICSI. * at least four follicles above 15 mm in diameter on the day of trigger * Downregulation using either GNRH antagonist or agonist protocol * Provision of written ,informed consent * BMI 18 to 35 kg per meter square
Exclusion criteria
* anticipated poor responder, according to Bologna criteria * cycle canceled prior to retrieval or without trigger administration * Oocyte cryoperservation cycles or natural IVF cycles * presence of ovarian pathology affecting the follicular assessment (endometriosis,cysts )
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total number of oocytes retrieved per participant during an ICSI cycle | From the start of controlled ovarian stimulation until the day of oocyte retrieval, assessed at oocyte retrieval (approximately 10-14 days after stimulation initiation and 34-36 hours after ovulation trigger). | The total number of oocytes retrieved will be recorded for each participant. Follicular number and mean follicular diameter will be measured by transvaginal ultrasound during ovarian stimulation, and their association with oocyte yield will be analyzed to determine minimum predictive thresholds for successful oocyte retrieval. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oocyte yield stratified by follicle size category and age group | From the start of controlled ovarian stimulation until the day of oocyte retrieval, assessed at oocyte retrieval (approximately 10-14 days after stimulation initiation and 34-36 hours after ovulation trigger). | The total number of oocytes retrieved per participant will be recorded and analyzed according to follicle size categories on the day of ovulation trigger. Participants will be stratified into predefined age groups (18-29 years and 30-35 years), and oocyte yield per follicle size category will be compared between age groups. |
Countries
Egypt
Contacts
CONTACTAhmad Rashad Mahmoud Mostafa, MBBCh
CONTACTKarima Sobhy M.Kholeif, Ph.D.
STUDY_CHAIRAlaa Ahmed Makhlouf, MD
Assiut University
STUDY_CHAIRAhmed Abo-Elfadle, MD
Assiut University
STUDY_CHAIRAhmed Mohamed Abo Elhasan Morsy, MD
Assiut University
Outcome results
None listed