Coronary Disease
Conditions
Keywords
Myocardial Ischemia, Cardiac rehabilitation, Quality of life, Frailty
Brief summary
Coronary artery disease (CAD) is a major chronic condition severely impacting population health in China. Our previous cohort studies revealed a high comorbidity rate between CAD and frailty, suggesting their interrelated equivalence as clinical syndromes with shared risk factors. In recent years, pilot integrated health management initiatives in China have demonstrated promising outcomes, yet evidence remains scarce regarding patients with concurrent CAD and frailty-a critical gap needing urgent resolution to achieve the Healthy China 2030 strategic goals. Building on prior research, this project aims to systematically evaluate existing management models for patients with CAD and frailty, develop a tailored health management framework, and implement it in clinical settings through empirical studies. The model will be optimized according to regional and demographic variations, leveraging cardiac rehabilitation centers, exercise-based interventions, and internet-enabled technologies to enhance coordinated care. By improving exercise efficacy, mitigating frailty progression, and enhancing quality of life, this initiative seeks to establish a robust chronic disease management system. The findings will provide evidence for formulating regional health policy and insurance strategies in Anhui Province, ultimately improving standardized management rates for chronic diseases.
Interventions
BEHAVIORALExercise rehabilitation plan and health management model for patients with coronary heart disease and frailty based on mobile health technology
The development, application and evaluation of an innovative health management model for patients with coronary heart disease and frailty based on the cardiac rehabilitation center framework, exercise rehabilitation, and new technologies such as mobile health.
Sponsors
The First Affiliated Hospital of Bengbu Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of Coronary heart disease; * Proficiency in smartphone use; * Absence of visual, auditory, cognitive, or motor impairments.
Exclusion criteria
* Inability or unwillingness to provide informed consent; * Physical or cognitive limitations preventing app operation; * Inability to attend in-person follow-up visits; * Concurrent severe comorbidities or malignancies, such as severe valvular heart disease, New York Heart Association class IV heart failure, severe aortic regurgitation, cancer, end-stage renal or liver disease; * Any other condition that could potentially impede exercise participation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 6MWD | 1month,3 months, 6 months | Measuring the maximum distance within 6 minutes. |
| The MOS item short from health survey | 1month,3 months, 6 months | Quality of life was assessed using the 36-Item Short Form Health Survey questionnaire |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gait speed | 1month,3 months, 6 months | Stopwatch |
| Physical activity level | 1month,3 months, 6 months | The short version self-reported International Physical Activity Questionnaire. |
| Frailty | 1month,3 months, 6 months | The FRAIL Scale |
| Major cardiovascular adverse events | 1month,3 months, 6 months | Major Adverse Cardiovascular Events (MACE) were defined as at least one of the following: heart failure, malignant arrhythmia, recurrent angina, recurrent myocardial infarction, cardiogenic shock, cardiac arrest, or sudden cardiac death. |
| Changes in Blood Lipid Biomarkers | 1 month, 3 months, 6 months | Changes in blood lipid biomarkers, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), were assessed. |
| Systolic pressure/Diastolic pressure | 1month,3 months, 6 months | Calibrated electronic blood pressure monitor |
| Grip strength | 1month,3 months, 6 months | Electronic grip device |
Countries
China
Outcome results
None listed