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Lidocaine Patch and Lower Third Molar

The Efficacy of a Transmucosal Lidocaine Patch on Postoperative Pain Following Mandibular Third Molar Extraction

Status
Not yet recruiting
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07330726
Enrollment
21
Registered
2026-01-09
Start date
2026-01-01
Completion date
2026-04-30
Last updated
2026-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted Third Molar Tooth

Brief summary

* Completed medical and dental history will take for all patients and the position of the impacted teeth will evaluate by panoramic films. Patients will fully inform about the treatment procedures, follow-up examinations and complications of surgical procedures. * Full thickness mucoperiosteal flap will be raised to expose sufficient bone on lateral and distal aspect of the impacted molar. Removal of bone will be done with stainless steel bur under Constant irrigation with normal saline while removing bone to prevent thermal necrosis. * When necessary, sectioning of crown and roots will be performed with a fissure bur. After tooth extraction, the alveolus will be inspected, curetted, and irrigated with 0.9% sterile saline solution. * Surgical removal of impacted mandibular third molar will be done,1% metformin gel or placebo gel in the socket following removal of the impacted third molar . * The mucoperiosteal flap will be repositioned and sutured with 3-0 black silk suture. * Control side : use transmucosal placebo patch * Study side: use transmucosal lidocaine patch Postoperative care * Postoperatively, the patients were instructed to apply ice bags 20 min/hour for the next 6 hours to the surgical side, eat soft cold diet by the aid of a straw and to avoid hot diet and fluid on the day of surgery. * Sutures were removed after 7 days postoperatively. * All the patients will be evaluated on the 1st, 3rd, and 7th postoperative days for pain, preoperative and postoperative mouth opening, and degree of postoperative swelling.

Interventions

transmucosal lidocaine patch after third molar tooth removal

DRUGplacebo patch

transmucosal placebo patch after third molar tooth removal

Sponsors

Fayoum University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* • Age ≥18ys * no systemic disease * impacted mandibular third molar class II position B on Pell- Gregory classification

Exclusion criteria

* • history of metabolic or systemic diseases affecting bone or healing process, * local infection, * tobacco use, * oral contraceptive, * pregnancy and lactation * patients who had taken analgesics or anti-inflammatories for 1 week prior to enrollment in the study.

Design outcomes

Primary

MeasureTime frameDescription
Pain intensity7 days postoperativePain was assessed using a visual analogue scale (VAS) of 10 units in combination with a graphic rating scale. On the VAS, the left most end represented the absence of pain (score 0) and the right most end indicated the most severe pain (score 10).

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026