Visceral Venous Thrombosis
Conditions
Brief summary
This study aims to evaluate the impact of genetic drivers (somatic and inherited thrombophilias), acquired risk factors, and management strategies on survival and clinical outcomes in patients with VVT using a hybrid prospective-retrospective cohort design.
Detailed description
Observational study (hybrid study comprising a retrospective and prospective cohort analysis): To evaluate the impact of genetic drivers (somatic and inherited thrombophilias), acquired risk factors, and management strategies on survival and clinical outcomes in patients with VVT using a hybrid prospective-retrospective cohort design. Data will be collected from the Department of Internal Medicine/hematology unit at Sohag University hospital and clinical databases. The retrospective component will include eligible patients diagnosed within the preceding ten years, whereas the prospective component will enroll newly diagnosed patients and follow them for one year. 1. Retrospective Cohort Analysis: Review of medical records to analyze demographic, clinical, and molecular data. Assessment of treatment regimens and outcomes, including thrombotic events, disease progression, and survival rates. 2. Prospective Cohort Analysis: Consecutive patients will be diagnosed with VVT from \[date of ethical approval\] forward, enrolled at diagnosis and followed prospectively with standardized baseline testing (including comprehensive genetic panel) and predefined follow-up visits.
Interventions
Radiological intervention Basic laboratory investigations, and Thrombophilia diagnosis
Sponsors
Sohag University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adult patients (≥ 18 years) with radiologically confirmed visceral venous thrombosis. * Availability of complete clinical, laboratory, and imaging data at diagnosis. * Patients who consent to participate and provide blood samples for genetic testing.
Exclusion criteria
* Isolated lower-limb deep-vein thrombosis or pulmonary embolism without visceral involvement. * Patients with incomplete records precluding outcome assessment. * Refusal or inability to provide informed consent * Patients lost to follow-up within the first three months of diagnosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patients diagnosed with visceral venous thrombosis | The retrospective component will include eligible patients diagnosed within the preceding ten years, whereas the prospective component will enroll newly diagnosed patients and follow them for one year. | To evaluate the impact of genetic drivers (somatic and inherited thrombophilias), acquired risk factors, and management strategies on survival and clinical outcomes in patients with VVT using a hybrid prospective-retrospective cohort design. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency and distribution | The retrospective component will include eligible patients diagnosed within the preceding ten years, whereas the prospective component will enroll newly diagnosed patients and follow them for one year. | To estimate the frequency of somatic mutations and inherited thrombophilias and describe their distribution across anatomical sites of VVT (portal, mesenteric, renal, splenic, hepatic) and underlying etiologies (autoimmune, inflammation, cirrhosis, malignancy, post-surgery, idiopathic). |
Countries
Egypt
Outcome results
None listed