Severe Asthma, Asthma Control Level
Conditions
Keywords
asthma, remission, Thailand, severe, FeNO, blood eosinophil count
Brief summary
The goal of this observational study is to determine the prevalence of remission among adults with severe asthma, as well as the factors associated with remission in Thailand. The main question the study aims to answer is: What is the prevalence of remission among adults with severe asthma in Thailand? Participants will complete questionnaires on asthma symptoms and undergo pulmonary function testing and a blood test once.
Detailed description
This study is a cross-sectional study. Thai patients aged 18 years or older with severe asthma are included in the study. Participants will complete two questionnaires about asthma control: the Global Initiative for Asthma (GINA) and the Asthma Control Test (ACT), and will perform spirometry, a fractional exhaled nitric oxide (FeNO) test, and blood eosinophil counts (BEC).
Interventions
GINA and ACT are questionnaires used to assess the level of asthma control.
DIAGNOSTIC_TESTSpirometry
Spirometry is a tool used to assess pulmonary function.
DIAGNOSTIC_TESTFractional exhaled nitric oxide (FeNO) test
FeNO is a tool used to assess eosinophilic airway inflammation and asthma remission.
DIAGNOSTIC_TESTBlood eosinophil count (BEC)
BEC is a tool used to assess eosinophilic inflammation and asthma remission.
Sponsors
Thammasat University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* severe asthma * age 18 years or older
Exclusion criteria
* inability to perform spirometry or fractional exhaled nitric oxide (FeNO) test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence rate of severe asthma remission | The beginning of the study | Prevalence rate of remission in adults with severe asthma |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association of clinical characteristics with severe asthma remission | The beginning of the study | The association between severe asthma remission and the following variables will be evaluated: 1. Asthma symptom control; Asthma Control Test (ACT) score (range 5-25) 2. Exacerbation history; Number of asthma exacerbations requiring systemic corticosteroids in the previous 12 months 3. Oral corticosteroid use; Daily oral corticosteroid use (yes/no) and cumulative dose (mg/year) 4. Asthma duration; Years since asthma diagnosis |
| Association of lung function with severe asthma remission | The beginning of the study | The association between severe asthma remission (binary outcome: remission vs. non-remission) and pulmonary function assessed using spirometry (FEV1 % predicted and FEV1/FVC ratio). |
| Association of inflammatory biomarkers with severe asthma remission | The beginning of the study | The association between severe asthma remission (binary outcome: remission vs. non-remission) and inflammatory biomarkers assessed using blood eosinophil count (cells/µL) and fractional exhaled nitric oxide (FeNO) (parts per billion, ppb). |
Contacts
Primary ContactNarongkorn Saiphoklang, MD
Backup ContactPacharaporn Tangsathapornpong, MD
Outcome results
None listed