ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT), Pulmonary Perfusion
Conditions
Brief summary
Although the theoretical model of cyclic on-off switching of pulmonary blood flow provides a crucial perspective for understanding VILI, its clinical validation and real-time intervention face significant obstacles. The fundamental reason lies in the lack of pulmonary microcirculation monitoring technology capable of bedside, non-invasive, continuous operation with sufficient spatiotemporal resolution. Nowadays, a novel 3D-EIT can perform real-time and non-invasive assessment of the distribution of pulmonary blood flow. However, if 3D-EIT can help to identify cyclic on-off switching of pulmonary blood flow is still unclear.
Interventions
None listed
Sponsors
Southeast University, China
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Adult patients with mechanical ventilation 2. diagnosis of moderate to severe ARDS no more than 72 hours
Exclusion criteria
1. Chronic respiratory diseases that required long-term oxygen therapy, such as pulmonary fibrosis or chronical obstructive pulmonary disease 2. Contraindications to EIT (e.g., active implantable device, chest malformation, unstable spinal injuries or fractures, and open chest wounds) 3. Undrained pneumothorax or pneumomediastinum, 4. Hemodynamic instability 5. Pregnancy 6. Refusal by family or the attending physician to participate in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The percent of Cyclic On-Off Switching | 15min | Cyclic On-Off Switching was assessed by 3D-EIT |
Countries
China
Contacts
Primary Contactling liu Liu, PhD
Outcome results
None listed