Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL

Comparison of Spinal and General Anesthesia on Systemic Inflammatory Response in Patients Undergoing Percutaneous Nephrolithotomy: Evaluation of SII, SIRI, AISI, NLR, and RDW

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07326670

Acronym

PCNL-ANES-INF

Enrollment

Registered

2026-01-08

Start date

2025-11-07

Completion date

2026-04-25

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia Techniques, Percutaneous Nephrolithotomy, Systemic Inflammation

Keywords

Percutaneous nephrolithotomy, Spinal anesthesia, Neutrophil-to-lymphocyte ratio, Red cell distribution width, Systemic inflammation

Brief summary

This observational study aims to compare the effects of spinal and general anesthesia on perioperative systemic inflammatory response in patients undergoing percutaneous nephrolithotomy (PCNL). Systemic inflammatory indices derived from routine complete blood count parameters, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW), will be evaluated. Preoperative and postoperative laboratory values will be analyzed to determine whether the type of anesthesia influences systemic inflammatory markers and related clinical outcomes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* American Society of Anesthesiologists (ASA) physical status class I-III * Patients aged 18 years and older

Exclusion criteria

* American Society of Anesthesiologists (ASA) physical status class IV or V * Patients younger than 18 years * Active infection or diagnosis of sepsis * Malignancy * Chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) * Use of immunosuppressive therapy * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Perioperative change in systemic inflammatory indices (SII, SIRI, AISI, NLR, RDW)	From preoperative period (within 6 hours before surgery) to postoperative period (6-24 hours after surgery)	Changes in Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW) will be evaluated using routine complete blood count parameters obtained preoperatively and postoperatively.

Countries

Turkey (Türkiye)

Outcome results