The Cold Ischemia Robot-assisted Partial Nephrectomy

The Impact of Cold Ischemia on Recovery From Ischemia After Robot-assisted Partial Nephrectomy: A Randomized Controlled Clinical Study

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07326280

Enrollment

310

Registered

2026-01-08

Start date

2024-01-01

Completion date

2026-12-31

Last updated

2026-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Cell Carcinoma, Renal Function Abnormal

Brief summary

To establish evidence that cold ischemia, achieved through the use of ice slush, can improve the recovery from ischemia on the operated kidney in patients undergoing robot-assisted partial nephrectomy.

Detailed description

Randomly dividing the study cohorts into two groups. One group undergoing cold ischemia partial nephrectomy and the other undergoing warm ischemia partial nephrectomy. Comparing the short-term renal function recovery between the two groups.

Interventions

PROCEDURECold ischemia robot-assisted partial nephrectomy

During the surgical procedure, employing ice to achieve local hypothermia in the kidneys.

PROCEDUREWarm ischemia robot-assisted partial nephrectomy

Not applying local hypothermia to the kidneys during the surgical procedure

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Intervention model description

Randomly dividing the study cohorts into two groups. One group undergoing cold ischemia robot-assisted partial nephrectomy，while the other group undergoing warm ischemia robot-assisted partial nephrectomy

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

\- 18 to 80 years old; 2. Intending to perform robot-assisted partial nephrectomy

Exclusion criteria

* Anesthesiologist assessment: Patient unsuitable for general anesthesia; * Having severe cardiovascular and cerebrovascular diseases; * horseshoe kidney; * pregnant women

Design outcomes

Primary

Measure	Time frame	Description
Recovery from ischemia	1-12 months after surgery	(%GFR saved)/(%parenchymal mass preserved)

Secondary

Measure	Time frame	Description
surgical duration	Intraoperative	The duration of the surgery
surgical complications	1-12 months after surgery	Intraoperative and postoperative complication incidence rate
The extent of decline in the long-term GFR (month13-24) on the operated kidney compared to the new baseline GFR(months 1-12).	up to 2 years after surgery	Postoperative short-term GFR(months 1-12) minus long-term GFR(month13-24)

Countries

China

Contacts

Primary ContactFangjian Zhou, professor

zhoufj@sysucc.org.cn020-87343865

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026